牙源性干细胞治疗帕金森病的研究进展

Advances in the treatment of dental stem cells for Parkinson′s disease

帕金森病(PD)是第二常见的神经退行性疾病,主要是由于中脑黑质(SN)多巴胺能神经元的丧失而导致运动功能障碍。牙源性干细胞(DSCs)来自颅神经嵴,易于采集,具有很强的增殖和分化能力,能够促进神经修复和再生。DSCs可以分化成新的多巴胺神经元并分泌大量神经营养因子(NTFs)改善神经功能,同时还可以通过免疫调节抑制神经炎性反应,DSCs可以有效减轻PD大鼠的运动功能障碍,并在再生医学领域中扮演着重要的角色。

Parkinson′s disease(PD)is the second most common neurodegenerative disease,mainly due to the loss of dopaminergic neurons in the substantia nigra(SN)of the midbrain,resulting in motor dysfunction.Dental stem cells(DSCs)are derived from the cranial neural crest which can be easily harvested.DSCs coming from the cranial neural crest have excellent proliferation and differentiation ability,and can promote nerve repair and regeneration.DSCs can secrete new dopamine neurons and secrete a large number of neurotrophic factors(NTFs)to improve the neural function,and also inhibit the neuroinflammatory response through immune modulation.DSCs can effectively alleviate the motor dysfunction in rats with PD and play an important role in R&D of regenerative medicine.