硫化氢在H型高血压中的研究进展

Research progress of hydrogen sulfide in H-type hypertension

硫化氢(hydrogen sulfide,H_(2)S)是一种参与血管张力调节的内源性气体传递素,具有多种生理特性,如抗高血压、血管松弛、抗炎和抗氧化潜能,在心血管调节中发挥重要作用。同型半胱氨酸(homocysteine,HCY)与心血管疾病的发生、发展密切相关。高同型半胱氨酸血症(HCY≥10μmol·L^(-1))是冠状动脉粥样硬化性心脏病、脑卒中等心脑血管疾病的危险因素,中国学者将伴有高同型半胱氨酸血症的原发性高血压定义为H型高血压,约占我国成年高血压患者的75%。H型高血压的治疗应同时降低血压和血浆HCY的水平。研究表明,H_(2)S能够拮抗高血压和高HCY,提示H_(2)S可能成为H型高血压的潜在治疗靶点。因此,该文就H_(2)S对高血压和HCY的作用机制进行总结。

Hydrogen sulfide(H_(2)S),an endogenous gas transmitter involved in the regulation of vascular tone,has a variety of physiological properties,such as antihypertensive,vascular relaxation,anti-inflammatory and antioxidant potential,and plays an important role in cardiovascular regulation.Chinese scholars call essential hypertension combined with hyperhomocysteinemia(HCY≥10μmol·L^(-1))as H-type hypertension.Studies have shown that H_(2)S can antagonized hypertension and hyperhomocysteinemia,suggesting that H_(2)S may be a potential therapeutic target for H-type hypertension.Therefore,this article briefly summarizes the mechanism of H_(2)S on hypertension and homocysteine.Homocysteine(HCY)is closely related to the occurrence and development of cardiovascular diseases.Hyperhomocysteinemia(HCY≥10μmol·L^(-1))is a risk factor for coronary atherosclerotic heart disease,stroke,and other cardiovascular diseases,and Chinese scholars define primary hypertension accompanied by hyperhomocysteinemia as H-type hypertension,which accounts for about 75%of the adult hypertensive patients in China.The treatment of H-type hypertension should simultaneously reduce blood pressure and plasma HCY levels.Studies have shown that hydrogen sulfide(H_(2)S)can antagonise hypertension and high HCY,suggesting that H_(2)S may be a potential therapeutic target for H-type hypertension.Therefore,this paper summarizes the mechanism of action of H_(2)S on hypertension and HCY.