无创通气治疗哮喘合并阻塞性睡眠呼吸暂停低通气综合征的效果观察

Effect of Non-invasive Ventilation in the Treatment of Asthma-obstructive Sleep Apnea Hypopnea Syndrome Overlap

目的:评价无创通气治疗哮喘合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的效果。方法:选取2022年9月至2024年1月泉州市第一医院收治的哮喘合并OSAHS患者72例作为研究对象,按照随机数字表法随机分为观察组和对照组,每组36例。对照组接受药物治疗,观察组接受药物治疗+持续气道正压通气(CPAP)治疗,12周评价效果。比较2组多导睡眠图(PSG)呼吸参数、睡眠参数、哮喘控制测试(ACT)评分与肺功能情况。结果:治疗后,观察组呼吸暂停低通气指数(AHI)显著低于对照组,最低血氧饱和度(LSpO_(2))、平均血氧饱和度(ASpO_(2))较高(P<0.05);治疗后,观察组的睡眠潜伏期(SL)短于对照组,睡眠效率(SE)与N3%高于对照组,N1%较低;治疗后,观察组的ACT评分、呼气高峰流量(PEF)与FEV1/FVC%均高于对照组(P<0.05)。结论:无创通气可在一定程度上改善哮喘合并OSAHS的治疗效果。

Objective:To evaluate the effect of non-invasive ventilation in the treatment of asthma-obstructive sleep apnea hypopnea syndrome(OSAHS)overlap.Methods:A total of 72 patients with asthma-OSAHS overlap were enrolled,randomly divided into study group and control group,with 36 cases in each group.The control group received drug treatment,the study group received drug treatment+CPAP.The effect was evaluated at 12th week.Respiratory and sleep parameters of polysomnography(PSG),ACT score and pulmonary function were compared.Results:After treatment,the apnea hypopnea index(AHI)of the study group was significantly lower than that of the control group,and the lowest blood oxygen saturation(LSpO_(2))and average blood oxygen saturation(ASpO_(2))were higher(P<0.05).After treatment,the sleep latency(SL)of the study group was shorter than that of the control group,and the sleep efficiency(SE)and N3%were higher than those of the control group,while N1%was lower.After treatment,the ACT score,peak expiratory flow(PEF),and FEV 1/FVC%of the study group were higher than those of the control group(P<0.05).Conclusion:Non invasive ventilation can improve the treatment effect of asthma combined with OSAHS to a certain extent.