TRPV3调节剂研究进展

Research progress of TRPV3 regulators

瞬时受体电位通道香草素亚族3(transient receptor potential vanilloid 3,TRPV3)是一种定位于细胞质膜的Ca^(2+)渗透性离子通道,除了温热(≥32℃)这一物理调控方式,TRPV3的活性受各种内源性和外源性的化学物质调控。利用这些化学调控,研究揭示了TRPV3的生理(温度感知、毛发生长)和病理(疼痛转导、皮肤炎症)功能,也提示TRPV3是具有潜力的药物开发靶点。本文综述了TRPV3调节剂的研究进展,以期为TRPV3的后续研究提供参考。

Transient receptor potential channel vanilloid 3(TRPV3)is a Ca^(2+)permeable channel,located in plasma membrane.Except physical regulation of warmth(≥32℃),the activity of TRPV3 is regulated by various endogenous and exogenous chemicals.With these chemicals,recent studies reveal physiological and pathological functions of TRPV3 including temperature sensing,hair growth,pain transduction,and skin inflammation,suggesting that TRPV3 is a potential drug development target.This article reviews the research progress of TRPV3 modulators,providing reference for subsequent researches on TRPV3.