苞叶雪莲化学成分及药理作用研究进展

Research Progress on Chemical Constituents and Pharmacological Effects of Saussurea obvallata

苞叶雪莲(Saussurea obvallata)是青藏高原地区特有的菊科风毛菊属植物,具有清热解毒、抗炎镇痛、通经活血等功效,是中国西藏、印度、巴基斯坦等地的传统药用植物。目前针对苞叶雪莲的现代药理学研究较少。苞叶雪莲的化学成分包括黄酮类、萜类、脂肪酸、生物碱等,现代药理学研究证实这些成分具有抗炎、抗氧化、抗肿瘤、调节免疫、保护心脑血管等多种作用。文章对苞叶雪莲的化学成分和药理作用研究进展进行了综述,为苞叶雪莲的进一步研究和新药开发提供参考。

Saussurea obvallata,Asteraceae,is native to Qinghai-Tibet Plateau and has been used as traditional medical plant in China,India and Pakistan due to its effect of antipyretic,antidotal,antiphlogistic and analgesic.However,few modern pharmacological studies about S.obvallata are available.The main chemical constituents isolated from S.obvallata include flavonoids,terpenoids,fatty acids,alkaloids,etc,which show effects on anti-inflammation,anti-oxidation,anti-tumor,immune regulation,cardiovascular protection and other effects.This paper reviews the current studies on its chemical constituents and pharmacological effects in order to provide reference for further research and drug development of S.obvallata.