肺炎球菌结合疫苗临床研究进展

Progress of clinical research on pneumococcal conjugate vaccine

肺炎球菌性疾病对人群健康、社会经济造成了较大的影响,已成为全球值得关注的公共卫生问题之一。目前肺炎球菌性疾病已被WHO列为需“极高度优先”使用疫苗预防的疾病。肺炎球菌疫苗主要包括肺炎球菌多糖疫苗和肺炎球菌结合疫苗。本文将以美国FDA批准的几款肺炎球菌结合疫苗为重点,简要介绍肺炎球菌结合疫苗的临床研究进展,以期为肺炎球菌结合疫苗的临床研发思路提供参考。

Pneumococcal disease has caused a significant impact on human health and social economy. It has become one of the public health problems worthy of attention in the world. The WHO classified pneumococcal disease as a “very high priority” for vaccine prevention. Pneumococcal vaccines mainly include pneumococcal polysaccharide vaccine and pneumococcal conjugate vaccine. This article focuses on several FDA-approved pneumococcal conjugate vaccines to briefly introduce the clinical research progress of pneumococcal conjugate vaccines, in order to provide reference for the clinical research and development of pneumococcal conjugate vaccine.