凝血酶在脑出血继发性损伤中的研究进展

Research progress of thrombin in secondary brain injury following intracerebral hemorrhage

脑出血是出血性卒中的一种亚型,具有较高的发病率和病死率。脑出血后引起的继发性损伤,如氧化应激(OS)、炎症反应、血液内容物(Fe、凝血酶)引起毒性反应,最终导致神经细胞功能缺损,严重影响患者生存及预后。凝血酶在高血压脑出血患者的脑组织中以中度和高度阳性表达为主。脑出血后大量凝血酶通过多种机制发挥作用,使凝血酶成为脑出血治疗的潜在靶点。本文就凝血酶参与脑出血后继发性脑损伤的相关作用机制进行综述。

Intracerebral hemorrhage is a subtype of hemorrhagic stroke,mortality rate.Secondary damage caused by cerebral hemorrhage which has a high incidence and,such as oxidative stress,inflammatory reaction,and toxic reactions caused by blood contents(Fe,thrombin),ultimately leads to neuronal dysfunction and significantly affects patients’survival and prognosis.Thrombin is mainly expressed as moderate to high levels in the brain tissue of hypertensive intracerebral hemorrhage patients.After cerebral hemorrhage,a large amount of thrombin exerts its effects through multiple mechanisms,making thrombin a potential therapeutic target for the treatment of cerebral hemorrhage.This article provides a comprehensive review of the mechanisms by which thrombin is involved in the secondary brain damage after cerebral hemorrhage.