肾周脂肪厚度与高尿酸血症患者痛风发作及发作频率的相关性研究

Peri-renal fat thickness is associated with gout attack and recurrent gout attacks in patients with hyperuricemia

目的探讨肾周脂肪厚度与高尿酸血症患者痛风发作及发作频率之间的关系。方法回顾性纳入2020年11月—2021年7月在首都医科大学附属北京潞河医院内分泌代谢与免疫性疾病中心接受治疗的高尿酸血症患者为研究对象,将其分为无痛风发作组(n=20)与有痛风发作组(n=80)。根据发作频率,将痛风发作组患者进一步分为发作1次组(n=44)与反复发作组(n=36)。收集纳入患者的人口学特征、疾病相关资料、内脏脂肪面积及肾周脂肪厚度,比较组间差异,并通过回归分析确定肾周脂肪厚度与痛风发作及发作频率的相关性。结果与无痛风发作组患者相比,有痛风发作组患者的肾周脂肪厚度增加[(1.09±0.39)cm比(1.37±0.45)cm,P=0.012];在有痛风发作组患者中,与发作1次组患者相比,反复发作组患者的肾周脂肪厚度增加[(1.26±0.40)cm比(1.50±0.47)cm,P=0.014]。Logistic回归分析显示,肾周脂肪厚度增加不仅与痛风发作存在相关,且与发作频率亦存在相关。结论肾周脂肪厚度与痛风发作及发作频率存在相关。

Objective To assess the connection between peri-renal fat thickness and gout attack frequency in patients with hyperuricemia.Methods A total of 100 patients with hyperuricemia were enrolled,with 20 patients having no history of gout attacks and 80 patients who have experienced gout attacks.The patients with gout attacks were further divided into a one-time attack group and a recurrent attack group.The demographic characteristics,disease-related data,visceral fat area,and peri-renal fat thickness of all patients were collected.We compared the differences between groups,investigated the correlation between peri-renal fat thickness and gout attack,and attack frequency by regression analysis.Results Patients with gout attacks had increased peri-renal fat thickness compared with those without gout attacks[(1.09±0.39)cm vs.(1.37±0.45)cm,P=0.012].Among patients with gout attacks,those with recurrent gout attacks had increased peri-renal fat thickness compared with those with only one attack[(1.26±0.40)cm vs.(1.50±0.47)cm,P=0.014].Logistic regression analysis indicated that increased peri-renal fat thickness was associated with both gout attacks and recurrent gout attacks.Conclusion Peri-renal fat thickness is associated with the occurrence and recurrence of gout.