阻塞性睡眠呼吸暂停低通气综合征与阿尔茨海默病生物标志物研究进展

Advances in biomarkers of obstructive sleep apnea hypopnea syndrome and Alzheimer disease

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)是成人和老年人群中最常见的睡眠障碍。近年来大量研究表明OSAHS会增加认知功能障碍的风险。本文总结OSAHS患者阿尔茨海默病(AD)相关的脑脊液及血浆生物标志物以及多种方法治疗OSAHS患者症状的同时也能改变AD生物标志物水平的研究结果,从而强调治疗OSAHS患者症状预防和延缓AD的发生发展的重要性。

Obstructive sleep apnea hypopnea syndrome(OSAHS)is one of the most common sleep disorders in both adults and the elderly.A large number of studies in recent years have shown that OSAHS may increase the risk of cognitive impairment.This article summarizes the latest research findings on cerebrospinal fluid and plasma biomarkers associated with Alzheimer disease(AD)in patients with OSAHS,as well as how various treatment methods for OSAHS can relief the symptoms of OSAHS and alter the levels of AD biomarkers simultaneously,so as to emphasize the importance of treating OSAHS symptoms to prevent and delay the development and progression of AD.