免疫细胞在缺血性脑卒中炎症反应中作用的研究进展

Research advances in the role of immune cells in inflammatory response to ischemic stroke

缺血性脑卒中(IS)由特定区域的脑动脉闭塞所致,是一种严重且危及生命的疾病。炎症反应贯穿于IS的全程,固有和适应性免疫细胞参与其中,促进IS后缺血脑组织的损伤和修复,并诱导全身免疫炎症反应。本文通过探究不同免疫细胞在IS后炎性反应中发挥的作用,总结归纳了一些免疫调节疗法,以期为IS的临床治疗寻找到新的方向。

Ischemic stroke(IS),caused by occlusion of cerebral arteries in specific regions,is a serious and lifethreatening disease.Inflammatory responses are present throughout the course of IS,and both innate and adaptive immune cells are involved,promoting injury and repair of ischemic brain tissue after IS and inducing systemic immune inflammatory response.This article investigates the role of different immune cells in inflammatory response after IS and summarizes several immunomodulatory therapies,in order to find new directions for the clinical treatment of IS.