缺血性卒中侧支循环的生物标志物的研究进展

Research advances in biomarkers for collateral circulation in ischemic stroke

缺血性卒中是因脑血管闭塞或者狭窄导致脑血流灌注下降,进而临床上表现出一些神经功能缺失症状的一类疾病总称,具有高发病率、高致残率、高死亡率以及高复发率的特性。当缺血性卒中发生时,血液通过其他开放或者新生的血管到达缺血区,从而代偿缺血组织,这些开放的血管吻合支或新生的血管统称为脑侧支循环,目前影像检查是评价侧支循环的主要方法,但受技术条件的限制。一些研究发现,生物标志物对侧支循环的状态及形成具有重要的提示意义,本文主要就缺血性卒中侧支循环生物标志物的研究进展进行综述。

Ischemic stroke is a group of diseases with the clinical manifestation of neurological deficits due to a reduction in cerebral blood perfusion caused by occlusion or narrowing of cerebral blood vessels,with the characteristics of high incidence rate,high disability rate,and high mortality rate.When ischemic stroke occurs,blood reaches the ischemic area through other open or new vessels to compensate for the ischemic tissue,and such open anastomotic branches or new vessels are collectively referred to as cerebral collateral circulation.At present,imaging examination is the main method for evaluating collateral circulation,but it is still limited by certain technical issues.Several studies have shown that biomarkers are important in reflecting the status and formation of collateral circulation,and this article reviews the research advances in the biomarkers for collateral circulation in ischemic stroke.