活动期肺结核患者凝血功能、血小板计数的变化及其意义

Changes in Coagulation Function and Platelet Count and Their Significance in Patients With Active Tuberculosis

目的分析活动期肺结核患者凝血功能、血小板计数变化及其意义。方法选取2021年3月—2023年8月南宁市第四人民医院结核科收治的180例肺结核患者,根据病变活动度将患者分为活动组(n=82)与非活动组(n=98),选取同时期健康体检者90例为对照组。测定3组凝血酶时间(thrombin time,TT)、D-二聚体(D-dimer,D-D)以及纤维蛋白原(fibrinogen,Fbg)、血小板计数(platelets,PLT)水平并比较。结果治疗后,活动组凝血功能、血小板计数水平均高于非活动组、对照组,非活动组均高于对照组(P<0.05);联合诊断AUC值最高,为0.965(0.942~0.987)。结论通过测定肺结核患者TT、D-D、Fbg、PLT水平,可有效预判患者是否处于疾病活动期,从而进行针对性的干预。

Objective To analyse the changes of coagulation function and platelet count in patients with active pulmonary tuberculosis and their significance.Methods A total of 180 patients with pulmonary tuberculosis admitted to the Fourth People's Hospital of Nanning from March 2021 to August 2023 were selected.The patients were divided into active group(n=82)and inactive group(n=98)according to the lesion activity,and 90 cases of those who had health checkup in the same period were selected as the control group.Thrombin time(TT),D-dimer(DD),fibrinogen(Fbg)and platelets(PLT)levels were measured and compared among the three groups.Results After treatment,the levels of coagulation function and platelet count in the active group were higher than those in the inactive group and the control group,and those in the inactive group were higher than those in the control group(P<0.05).The AUC value of the combined diagnosis was the highest,0.965(0.942-0.987).Conclusion By measuring the levels of TT,D-D,Fbg and PLT in patients with pulmonary tuberculosis,it is possible to effectively predict whether the patient is in the active phase of the disease and carry out targeted interventions.