7项肿瘤自身抗体检测对肺癌诊断价值的Meta分析

Meta-Analysis of the Diagnostic Value of Seven Tumor-Associated Autoantibodies in Lung Cancer

目的采用Meta分析的方法系统评价7项肿瘤相关自身抗体(tumor-associated autoantibodies,TAAbs)在肺癌诊断中的价值。方法计算机检索CNKI、WanFang Data、VIP、CBM、PubMed、Embase等数据库,获取2015年1月—2023年5月的关于7-TAAbs对肺癌诊断价值的相关文献。通过Revman 5.3软件对文献进行系统质量评价和偏倚风险评估。采用Stata 17.0、Meta DiSc 1.4软件将灵敏度(sensitivity,Sen)、特异度(specificity,Spe)等指标进行Meta分析。结果本研究共纳入31篇文献,基于此,进行Meta分析的结果显示,7-TAAbs作为肺癌诊断指标时Sen=0.56(95%CI 0.52~0.60),Spe=0.87(95%CI 0.84~0.89),阳性似然比(positive likelihood ratio,PLR)为4.18(95%CI 3.58~4.88),阴性似然比(negative likelihood ratio,NLR)为0.51(95%CI 0.47~0.55),诊断比值比(diagnostic odds ratio,DOR)为8.05(95%CI 6.60~9.83),受试者工作曲线下面积(area under the ROC curve,AUC)为0.80(95%CI 0.76~0.83)。Meta回归与亚组分析显示研究的异质性来源于病例的发表年份、研究类型、病理类型及样本数量。Deeks'漏斗图检验结果提示未发现明显的发表偏倚(P>0.05)。结论7-TAAbs作为肺癌诊断指标时灵敏度中等,特异度较高,具有较好的诊断价值。

Objective This study aims to evaluate the diagnostic value of seven tumor-associated autoantibodies(TAAbs)for lung cancer by applying literature review and Meta-analysis.Methods The relevant literatures on the diagnostic value of 7-TAAbs in lung cancer from January 2015 to May 2023 were retrieved from CNKI,Wanfang Data,VIP,CBM,PubMed,Embase and other databases by computer.Systematic quality evaluation and bias risk assessment were carried out by Revman 5.3 software.Sensitivity(Sen)and specificity(Spe)were used for Meta analysis by Stata 17.0 and Meta DiSc 1.4.Results A total of 31 literatures were included in this study.Based on this,the results of Metaanalysis showed that when 7-TAAbs was used as a diagnostic indicator for lung cancer,Sen=0.56(95%CI 0.52-0.60)and Spe=0.87(95%CI 0.84-0.89),positive likelihood ratio(PLR)was 4.18(95%CI 3.58-4.88),negative likelihood ratio(NLR)was 0.51(95%CI 0.47-0.55),Diagnostic odds ratio(DOR)was 8.05(95%CI 6.60-9.83),and the Area under the ROC curve(AUC)was 0.80(95%CI 0.76-0.83).Meta-regression and subgroup analysis showed that the heterogeneity of the study was due to the year of publication,study type,pathological type and sample size.The results of Deeks'funnel plot showed that no significant publication bias was found(P>0.05).Conclusion 7-TAAbs have good diagnostic performance for lung cancer,with moderate sensitivity and good specificity.