两种不同治疗方法治疗婴幼儿泪囊炎的疗效对比分析

A comparative study on curative effects of two different medication in the treatment of infantile dacryocystitis

目的比较泪道探通术+鱼腥草滴眼液与泪道探通术+妥布霉素滴眼液冲洗治疗婴幼儿泪囊炎的疗效。方法将2021年8月至2022年8月在保定市妇幼保健院接受治疗的200例患有泪囊炎的2个月~2岁婴幼儿纳入本次前瞻性研究。按照随机数字表法将其分为鱼腥草组(n=100)和妥布霉素组(n=100)。鱼腥草组患儿接受泪道X线造影+鱼腥草滴眼液冲洗+泪道探通术治疗;妥布霉素组患儿接受泪道X线造影+妥布霉素滴眼液冲洗+泪道探通术治疗。比较两组的临床疗效、1次探通成功率、治疗前后血清炎症因子[白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)和高敏C反应蛋白(hs-CRP)]水平、并发症发生情况及术后复发情况。结果鱼腥草组和妥布霉素组的总有效率比较(90.00%vs.95.00%),差异无统计学意义(P>0.05)。鱼腥草组与妥布霉素组的1次探通成功率比较(91.00%vs.96.00%),差异无统计学意义(P>0.05)。治疗后,两组的血清IL-6、TNF-α和hs-CRP水平均较治疗前显著下降,差异均有统计学意义(P<0.05);鱼腥草组与妥布霉素组治疗后的血清IL-6、TNF-α和hs-CRP水平比较[(2.52±0.71)pg/mL vs.(2.39±0.65)pg/mL,(5.18±1.61)pg/mL vs.(5.05±1.57)pg/mL,(10.57±2.46)mg/L vs.(10.10±2.27)mg/L],差异均无统计学意义(P>0.05)。鱼腥草组与妥布霉素组的并发症发生率(7.00%vs.4.00%)和术后复发率(0 vs.0)比较,差异均无统计学意义(P>0.05)。结论鱼腥草滴眼液冲洗+泪道探通术治疗婴幼儿泪囊炎的临床疗效与妥布霉素滴眼液冲洗+泪道探通术相当,且安全性高,术后不易复发。

Objective To compare the curative effects of houttuynia cordata eyedrops irrigation and tobramycin eyedrops irrigation combination with lacrimal duct probing in the treatment of infantile dacryocystitis.Methods Two hundreds infants aged 2 months to 2 years with dacryocystitis who received treatment at the Baoding Maternal and Child Health Hospital from August 2021 to August 2022 were included in this study and were randomly divided into the houttuynia cordata group(n=100)and the tobramycin group(n=100).The houttuynia cordata group underwent lacrimal duct X-ray imaging+irrigation with houttuynia cordata eyedrops+lacrimal duct probing for treatment,while the tobramycin group underwent lacrimal duct X-ray imaging+irrigation with tobramycin eyedrops+lacrimal duct probing.The clinical efficacy,success rate of initial probing,serum inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α),and high-sensitivity C-reactive protein(hs-CRP)]levels before and after treatment,occurrence of complications,and recurrence rate of the two groups were compared.Results There was no statistically significant difference in the total effective rate of the houttuynia cordata group and the tobramycin group(90.00%vs.95.00%)(P>0.05).There was no statistically significant difference in the success rate of initial probing in the Houttuynia cordata group and the Tobramycin group(91.00%vs.96.00%)(P>0.05).After treatment,the levels of serum IL-6,TNF-αand hs-CRP in two groups were significantly lower than those before treatment,and the differences were statistically significant(P<0.05);there were no statistically significant differences in the levels of serum IL-6,TNF-αand hs-CRP[(2.52±0.71)pg/mL vs.(2.39±0.65)pg/mL,(5.18±1.61)pg/mL vs.(5.05±1.57)pg/mL,(10.57±2.46)mg/L vs.(10.10±2.27)mg/L]in the houttuynia cordata group and tobramycin group after treatment(P>0.05).There were no statistically significant differences in the incidence of complications(7.00%vs.400%)and postoperative recurrence rate(0 vs.0)between the houttuynia cordata group and the tobramycin group(P>0.05).Conclusion Irrigation with houttuynia cordata eyedrops+lacrimal duct probing have comparable clinical efficacy to irrigation with tobramycin eyedrops+lacrimal duct probing in the treatment of infantile dacryocystitis.Both treatment methods are safe and have low recurrence rates after surgery.