腹腔镜下卵巢巨大囊肿剔除术对患者卵巢功能、炎症因子及T淋巴细胞亚群水平的影响

Effect of laparoscopic excision ofgiant ovarian cysts on ovarian function,inflammatory factors and T lymphocyte subsets in patients

目的探究腹腔镜下卵巢巨大囊肿剔除术对患者卵巢功能、炎症因子及T淋巴细胞亚群水平的影响。方法前瞻性随机选取本院收治的卵巢巨大囊肿患者76例,将其用随机数字表法分成对照组和观察组,各38例。对照组行传统开腹卵巢巨大囊肿剔除术,观察组行腹腔镜下卵巢巨大囊肿剔除术。比较2组围术期相关指标、应激指标水平、卵巢功能、炎症因子水平、T淋巴细胞亚群水平及术后并发症发生情况。结果观察组手术、住院时间短于对照组,出血量少于对照组(P<0.05)。术后,2组皮质醇(cortisol,Cor)、肾上腺素(adrenaline,A)水平和视觉模拟评分法(visual analogue scale,VAS)评分均有升高,但观察组低于对照组(P<0.05)。术后,2组促黄体生成素(uteinizing hormone,LH)、卵泡刺激素(follicle stimulating hormone,FSH)水平均有升高,但观察组低于对照组(P<0.05)。2组超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、白细胞介素6(interleukin-6,IL-6)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)水平均有升高,但观察组低于对照组(P<0.05)。2组CD3^(+)、CD4^(+)/CD8^(+)水平均有下降,但观察组高于对照组(P<0.05)。观察组术后并发症少于对照组(P<0.05)。结论与传统开腹手术相比,腹腔镜下卵巢巨大囊肿剔除术能明显减轻患者应激反应,术后炎症水平较低、对患者卵巢功能及免疫功能损伤较小,术后并发症较少,临床应用价值更高。

Objective To explore the effect of laparoscopic excision of giant ovarian cystson ovarian function,inflammatory factors and T lymphocyte subsets in patients.Methods A total of 76 patients with giant ovarian cysts treated in our hospital were prospectively randomly selected.They were divided into control group and observation group according to random number table method,with 38 patients in each group.The control group received traditional open surgery for the removal of giant ovarian cysts,and the observation group underwent laparoscopic removal of ovarian giant cysts.The perioperative related indicators,stress indicators,ovarian function,inflammatory factors,T lymphocyte subsets and postoperative complications were compared between the two groups.Results The duration of operation and the length of hospitalization in the observation group were shorter than those in the control group,and the blood loss of the observation group was less than that of the control group(P<0.05).After operation,cortisol(Cor),adrenaline(A)levels and visual analogue scale(VAS)scores were increased in the two groups,which,however,were lower in the observation group than in the control group(P<0.05).After operation,the levels of luteinizing hormone(LH)and follicle stimulating hormone(FSH)in the two groups were increased,but the levels were lower in the observation group than in the control group(P<0.05).After operation,the levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the two groups were increased,but the levels in the observation group was lower than those in the control group(P<0.05).After operation,the levels of CD3^(+),CD4^(+)/CD8^(+)in the two groups were decreased,but the levels in the observation group were higher than those in the control group(P<0.05).The postoperative complications in the observation group were fewer than those in the control group(P<0.05).Conclusion Compared with traditional open surgery,laparoscopic excision of giant ovarian cysts can significantly reduce the stress response of patients,with lower postoperative inflammation,less damage to ovarian function and immune function,fewer postoperative complications,and higher clinical application value.