生脉饮合丹参饮在阴虚血瘀型冠心病治疗中的价值及对患者炎症指标的影响研究

Study on the value of Shengwei Drink combined with Danshen Drink in the treatment of Yin deficiency and blood stasis type coronary heart disease and its effect on patients'inflammatory indexes

目的:评价生脉饮合丹参饮在阴虚血瘀型冠心病治疗中的价值及对患者炎症指标的影响。方法:选择2021年9月~2022年12月来我院治疗的冠心病患者114例,依据治疗方式的不同可分为观察组和对照组,每组57例。两组均给与常规治疗,观察组在对照组治疗的基础上,口服生脉饮合丹参饮治疗。比较两组治疗前后阴虚血瘀型冠心病的相关症状,评估患者的心脏功能,包括左室收缩末内径(LVESD)、左室舒张末内经(LVEDD)、左室射血分数(LVEF),评价两组患者硝酸甘油减停率,比较血清学指标IL-6、TNF-α和CRP,比较治疗疗效。结果:经过3个月的治疗,观察组患者中达到显效标准的有43例,达到有效标准的有10例,无效甚至恶化的有4例,总治疗有效率为53(92.98%)。对照组患者中达到显效标准的有37例,达到有效标准的有8例,无效甚至恶化的患者有12例,治疗总有效率为45(78.95%)。观察组治疗总有效率高于对照组(P<0.05);观察组治疗后胸痛、胸闷、心悸、失眠多梦等证候积分低于对照组(P<0.05);两组患者心电图指标均较治疗前有所改善,且观察组患者改善幅度优于对照组(P<0.05);研究组硝酸甘油减停率优于对照组(P<0.05);两组治疗后血清学指标IL-6、TNF-α和CRP较治疗前降低,且观察组降低幅度优于对照组(P<0.05)。结论:生脉饮合丹参饮治疗阴虚血瘀型心脏病疗效显著,可有效的改善患者的临床症状,降低炎症因子水平,患者心室缺血症状,从而促进预后。

Objective:To evaluate the value of Shengmai Drink combined with Danshen Drink in the treatment of coronary artery disease of yin deficiency and blood stasis type and the effect on patients'inflammatory indexes.Methods:114patients with coronary artery disease who came to our hospital for treatment from September 2021to December 2022were selected and divided into observation group and reference group according to the different treatment modes,with 57cases in each group.Both groups were given conventional treatment,and the observation group was treated with oral administration of Shengmai Drink and Danshen Drink on the basis of the treatment of the reference group.We compared the symptoms related to Yin deficiency and blood stasis type coronary heart disease before and after treatment,assessed the patients'cardiac function,including left ventricular end-systolic internal diameter(LVESD),left ventricular end-diastolic internal meridian(LVEDD),left ventricular ejection fraction(LVEF),evaluated the rate of nitroglycerin reduction in the patients of the two groups,and compared the serological indexes of IL-6,TNF-alpha,and CRP,and compared the efficacy of the treatment.Results:After 3months of treatment,43cases of patients in the observation group reached the obvious effect standard,10cases reached the effective standard,and 4cases were ineffective or even deteriorated,and the total treatment effectiveness rate was 53(92.98%).In the reference group,there were 37cases of patients who met the criteria of obvious effect,8cases of patients who met the criteria of effective,12cases of patients who were ineffective or even deteriorated,and the total effective rate of treatment was 45(78.95%).The total effective rate of treatment in the observation group was higher than that in the reference group(P<0.05);the symptom points of chest pain,chest tightness,palpitation,insomnia and dreaminess after treatment in the observation group were lower than those in the reference group(P<0.05);the ECG indexes of the patients in the two groups improved compared with the pre-treatment period and the magnitude of the improvement of the patients in the observation group was superior to that of the reference group(P<0.05);the rate of nitroglycerin reduction in the study group was superior to that of the reference group(P<0.05);the serological indexes of IL(IL)in both groups were better than those of the reference group(P<0.05)after treatment.After treatment,the serological indexes IL-6,TNF-α and CRP were reduced compared with those before treatment,and the magnitude of reduction in the observation group was better than that in the reference group(P<0.05).Conclusion:The efficacy of Sheng pulse drink combined with Danshen drink in the treatment of yin deficiency and blood stasis type of heart disease is remarkable,which can effectively improve the clinical symptoms of the patients,reduce the level of inflammatory factors,and the symptoms of ventricular ischemia in patients,thus promoting the prognosis.