四仙颗粒治疗化疗后血小板减少的疗效观察

Efficacy of Sixian Granules in the Treatment of Thrombocytopenia After Chemotherapy

目的:抗肿瘤的化疗药物大多会引起患者骨髓造血功能障碍,往往导致治疗不能按时、按量进行,影响化疗效果。血小板下降是骨髓功能被抑制的表现之一,目前虽然皮下注射“白介素-11”、“TPO”对提升血小板疗效肯定,但因价格昂贵等原因,在临床上受到一定的限制。而采用口服的、价格较为低廉的药物来有效治疗化疗后血小板减少的报道甚少。本研究探讨笔者自拟中药“四仙颗粒”对化疗后血小板减少的治疗效果。方法:2015年2月~2016年12月共观察65例化疗后血小板减少患者。其中治疗组33例,除常规对症治疗外,还每天分3次服用“四仙颗粒”1剂,连服2周。对照组32例,仅行常规对症治疗,观察2周。结果:治疗组显效率21.2%,有效率51.5%,总有效率73.7%;对照组显效率12.5%,有效率37.5%,总有效率25.0%,两组比较,有显著性差异(P<0.01)。结论:“四仙颗粒”能有效提升化疗后下降的血小板水平。

PURPOSE:Most of the anti-tumor chemotherapy drugs can cause hematopoietic dysfunction of bone marrow in patients,which often leads to treatment that cannot be performed on time and according to the amount,which affects the effect of chemotherapy.Thrombocytopenia is one of the manifestations of inhibition of bone marrow function.Although subcutaneous injection of“interleukin-11”and“TPO”is effective in improving platelets,it is clinically limited due to high price.There are few reports of effective treatment of thrombocytopenia after chemotherapy with oral,relatively inexpensive drugs.This study explored treatment effect of the author's self-made Chinese medicine“Sixian Granule”on thrombocytopenia after chemotherapy.METHODS:A total of 65patients with thrombocytopenia after chemotherapy were observed from February 2015to December 2016.Among them,33patients who whtook 1dose of“Sixian Granules”3times a day for 2weeks in addition to conventional symptomatic treatment were in the treatment group.In the control group,32patients were treated with conventional symptomatic treatment for 2weeks.RESULTS:The significant efficiency of the treatment group was 21.2%,the effective rate was 51.5%,and the total effective rate was 73.7%.The significant efficiency of the control group was 12.5%,the effective rate was 37.5%,and the total effective rate was 25.0%.There was significant difference between the two groups(P<0.01).CONCLUSION:“Sixian Granule”can effectively increase the decreased platelet level after chemotherapy.