基于“肝-脑-目”轴探讨中医药论治干眼

Treatment of dry eyes with Chinese Medicine based on"liver-brain-eye"axis

“肝”“脑”“目”三者在生理及病理上相互联系,形成了“肝-脑-目”轴交互体系。其关系存在多向交互串扰,影响干眼的发生发展。应用脏腑辨证理论从生理和病理两个层面对“肝-脑-目”轴的内涵进行阐述,并提出“肝-脑-目”轴的3种失衡状态及其与干眼发病的关系,且肝、肾与目的关系为“肝-脑-目”轴理论之关键。提出清肝疏肝以畅“肝-脑-目”轴、益精生髓以充“肝-脑-目”轴、补肝肾阴以理“肝-脑-目”轴的中医药治疗干眼思路,以期为临床治疗干眼提供参考。

The"liver","brain",and"eye"are intimately connected both physiologically and pathologically,constituting an interactive system known as the"liver-brain-eye"axis.This axis exhibits multi-directional interactions and crosstalk,influencing the onset and progression of dry eyes.This paper employs the theory of pattern identification of zang-fu organs to expound on the connotations of the"liver-brain-eye"axis from both physiological and pathological perspectives.It proposes three states of disequilibrium within the"liver-brain-eye"axis and their associations with the pathogenesis of dry eyes,emphasizing that the relationship among the liver,kidney,and eyes is pivotal to the"liver-brain-eye"axis theory.To offer ideas to dry-eye treatment as clinical references,this paper introduces the concepts of Chinese medicine:clearing and soothing the liver to harmonize the"liver-brain-eye"axis,tonifying essence and generating marrow to replenish the"liver-brain-eye"axis,and nourishing liver and kidney yin to regulate the"liver-brain-eye"axis.