破伤风高风险人群主动免疫制剂使用专家共识

Expert consensus on the use of tetanus vaccines for the high-risk group of post-traumatic tetanus

目前在全球范围内破伤风仍然是一种极为严重的潜在致死性疾病。我国已于2012年消除新生儿破伤风,但外伤后破伤风的疾病负担较重。针对我国外伤后破伤风高发病风险人群做好暴露前主动免疫,对于降低我国外伤后破伤风疾病负担具有重要意义。本共识依据世界卫生组织破伤风疫苗立场文件以及中国发布的破伤风相关规范、标准,并结合国内外相关研究结果,介绍了国内外破伤风暴露前免疫预防策略、我国破伤风发病高风险人群的界定等内容,并对暴露前破伤风主动免疫制剂的使用形成了推荐意见,供疾病预防控制和预防接种相关工作人员参考使用。

Tetanus remains a potentially fatal disease with highly severe consequences worldwide.China has eliminated neonatal tetanus since 2012,but post-traumatic tetanus still represents a substantial public health burden.It is of great significance to implement active pre-exposure immunization among the high-risk group of post-traumatic tetanus in China,which can help reduce the burden of post-traumatic tetanus.Based on the World Health Organization's position paper on tetanus vaccines and relevant regulations and standards issued by China,this consensus introduces the pre-exposure immunization prevention strategies for tetanus both domestically and internationally,as well as the definition of a high-risk group of post-traumatic tetanus in China.It also provides recommendations on using active immunological preparation for tetanus,which can be used as a reference for relevant personnel engaged in disease prevention,control,and vaccination.