生命早期饥荒对壮族居民成年后心血管疾病危险因素的影响

The impact of early life famine on cardiovascular risk factors in the Zhuang ethnic minority residents in adulthood

目的探讨生命早期经历严重饥荒对壮族居民发生心血管疾病风险因素聚集性的影响。方法选取年龄≥40岁的1957名壮族城乡居民作为研究对象,按出生日期将研究对象分为胎儿期组(n=176),儿童期组(n=654)、青少年期组(n=101)、未经历组(n=1026)。比较各组间的指标水平与代谢异常风险的差异,分析生命早期饥荒暴露与心血管危险因素的聚集性关系。结果Logistic回归分析显示,调整混杂因素后,生命早期经历饥荒是发生高血压、糖尿病、血脂异常和心血管疾病危险因素聚集的影响因素;胎儿期、儿童期、青少年期经历饥荒暴露发生2种心血管危险因素的风险是未经历饥荒的3.15倍(OR=3.15,95%CI:1.60~6.21,P<0.05)、3.76倍(OR=3.76,95%CI:2.52~5.62,P<0.05)和2.76倍(OR=2.76,95%CI:1.31~5.82,P<0.05)。结论生命早期饥荒暴露可增加壮族居民成年后心血管疾病危险因素的发生风险,践行生命早期合理干预,可有效预防成年后心血管疾病危险因素的发生。

Objective To investigate the effects of the severe early life famine on the clustering of cardiovascular disease risk factors among Zhuang ethnic minority residents.Methods A total of 1957 urban and rural Zhuang ethnic minority residents aged 40 and above were taken as the study subjects.The study subjects were divided into the fetal experience group(n=176),childhood experience group(n=654),adolescent experience group(n=101),and non-exposure group(n=1026)according to the date of birth.Differences in index levels and risk of metabolic abnormalities between groups were compared to analyze the aggregated relationship between early life famine exposure and cardiovascular risk factors.Results Logistic regression results showed that after adjusting for confounders,experiencing famine early in life was a risk factor for the development of hypertension,diabetes mellitus,dyslipidemia,and cardiovascular disease risk factor clustering;the risk of developing two cardiovascular risk factors from famine exposure during fetal life,childhood,and adolescence was 3.15 times(OR=3.15,95%CI:1.60-6.21),3.76 times(OR=3.76,95%CI:2.52-5.62),and 2.76 times(OR=2.76,95%CI:1.31-5.82)(P<0.05).Conclusions Early life famine exposure increases the risk of cardiovascular disease risk factors in Zhuang ethnic minority residents in adulthood,and practicing reasonable interventions early in life can effectively prevent the occurrence of cardiovascular disease risk factors in adulthood.