摘要
Metabolism is mobilized to meet the biosynthetic,bioenergetic,and regulatory demands of immune cell activation.Almost nothing is known about the metabolic basis of antibody class switch in B cells.A recent study published in Nature Communications through a joint effort by Chen Lab(metabolism biology)and Liu Lab(B cell biology)from Tsinghua University reveals that the monocarboxylate carrier MCT1(monocarboxylate transporter 1)promotes pyruvate oxidation and histone acetylation to support class switch recombination(CSR),the process by which B cells make antibodies of different isotypes with unique effector functions.
