肠道菌产生酶与天然药物互作对疾病的影响

Interactions between gut microbiota-producing enzymes and natural drugs affect disease progression

天然来源的代谢产物是药物研发的宝贵资源,对疾病的治疗起重要作用。肠道菌群作为机体的“第二基因组”,蕴含丰富的物质代谢酶,可与机体摄入的药物等外来物质相互作用,改变疾病进程。本文总结了肠道菌产生酶与天然药物之间的互作关系,并重点探讨了这种互作关系对疾病的影响,希望能为天然药物的研发及药理机制的探究提供新思路。

Naturally derived metabolites are valuable resources for drug research and development,and play an important role in the treatment of diseases.As the"second genome"of the body,gut microbiota is rich in metabolic enzymes,which interacts with external substances such as drugs,thus affecting the progression of diseases.This article summarizes the interaction between gut microbiota-producing enzymes and natural medicines,and focuses on the impact of this interaction on disease progression,hoping to provide new ideas for the development and pharmacological mechanism of natural medicines.