摘要
骨愈合和骨再生是维持骨稳态的复杂生理过程,其中间充质干细胞作为成骨细胞的主要来源在其中发挥着重要作用。研究表明,长链非编码RNA(long non-coding RNA,lncRNA)广泛参与调节间充质干细胞的成骨分化,其中小核仁RNA宿主基因(small nucleolar RNA host gene,SNHG)作为近年来新发现的一类非编码基因家族,可通过多种途径调控间充质干细胞成骨分化,有望成为骨代谢和骨再生治疗中的新靶点。因此,本文旨在总结SNHG家族基因在间充质干细胞成骨过程中的作用机制。
Bone healing and bore regeneration are complex processes in maintaining normal bone homeostasis.Mesenchymal stem cells are main resource of osteoblasts that are responsible for bone formation.Long noncoding RNA(lncRNA)is emerging as important regulatory role in the osteogenic differentiation of mesenchymal stem cells,in which lncRNA small nucleolar RNA host gene(SNHG)has been shown to be participated in mesenchymal stem cell osteogenic differentiation via various mechanisms,promising to be a new therapeutic target in bone metabolism and bone regeneration therapy.Herein,this article aims to review the biological functions and emerging mechanisms of SNHG involved in the mesenchymal stem cell osteogenic differentiation.
作者
黄洁
王佐林
HUANG Jie;WANG Zuolin(Shanghai Engineering Research Center of Tooth Restoration and Regeneration&Tongji Research Institute of Stomatology&Department of Oral Implantology,Stomatological Hospital and Dental School,Tongji University,Shanghai 200072,China)
出处
《口腔颌面外科杂志》
CAS
2024年第4期306-309,共4页
Journal of Oral and Maxillofacial Surgery
基金
科技部重大研发专项(2018YFE0202200)
国家自然科学基金(81670962)。
