人参皂苷抗结直肠癌作用及机制的研究进展

Progress of researches on the activity of ginsenoside against colorectal cancer and the underlying mechanisms

研究发现,多种人参皂苷活性成分在结直肠癌治疗中表现出良好的抗肿瘤效果,其机制涉及抑制癌细胞增殖、诱导凋亡、化疗与放疗增敏、抑制侵袭迁移与上皮细胞-间充质转化、调节肠道菌群、改善肿瘤免疫微环境等。本文就人参皂苷抗结直肠癌的药理活性及作用机制进行综述。

Objective Multiple active ingredients of ginsenoside have shown a high activity against colorectal cancer,and the underlying mechanisms include suppression of cancer cell proliferation,induction of apoptosis,increased sensitivity to chemotherapy and radiotherapy,inhibition of cancer invasion and migration and epithelial-mesenchymal transition,regulation of gut microbiota and improvements of tumor immune microenvironments.This article reviewed the pharmacological activity of ginsenoside against colorectal cancer and the underlying mechanisms of actions.