玫瑰痤疮治疗中水光注射氨甲环酸辅助点阵激光的临床疗效

Clinical Efficacy of the Mesotherapy with Tranexamic Acid Assisted Fractional Laser in the Treatment of Rosacea

目的 观察玫瑰痤疮治疗中水光注射氨甲环酸辅助点阵激光的治疗效果。方法 选取2019年6月—2022年3月于本院就诊的玫瑰痤疮患者82例,根据治疗方式将其分为激光组40例和联合组42例。比较治疗前后2组患者红斑面积、红斑指数和皮肤状态;比较治疗后2组临床疗效和不良反应。结果 治疗后联合组红斑面积小于激光组[(39.45±7.36)mm^(2)比(50.24±6.15)mm^(2),(P<0.05)],红斑指数、经皮水分散失(TEWL)和乳酸刺痛实验(LAST)评分均低于激光组[红斑指数:(0.98±0.14)比(1.37±0.25),TEWL:(9.96±2.33)g/(m^(2)·h)比(13.02±2.28)g/(m^(2)·h),LAST评分:(0.91±0.14)分比(1.43±0.29)分,均P<0.05]。联合组临床总有效率高于激光组(95.24%比80.00%,P<0.05)。激光组、联合组一过性潮红、局部皮肤发红、色素沉着、轻微肿胀发生率比较,差异无统计学意义(P>0.05)。结论 玫瑰痤疮治疗中采用水光注射氨甲环酸辅助点阵激光可提高治疗效果,改善患者皮肤状态,且安全性高。

Objective In order to investigate the therapeutic effects of the mesotherapy with tranexamic acid assisted fractional laser in the treatment of rosacea.Methods Eighty-two patients with rosacea from our outpatient clinic between June 2019 and March 2022 were divided into laser group(40 cases)and combined group(42 cases)according to treatment modality.The erythema area,erythema index,and skin condition of both groups were compared before and after treatment.And the clinical efficacy and adverse effects of both groups were compared after treatment.Results After treatment,the erythema area of the combined group was smaller than that of the laser group[(39.45±7.36)mm^(2) vs.(50.24±6.15)mm^(2)],and the erythema index,transepidermal water loss(TEWL),and Lactic Acid Sting Test(LAST)score of the combined group were lower than those of the laser group,respectively[erythema index:(0.98±0.14)vs.(1.37±0.25),TEWL:(9.96±2.33)g/(m^(2)·h)vs.(13.02±2.28)g/(m^(2)·h),LAST:(0.91±0.14)min vs.(1.43±0.29)min](all P<0.05).The total clinical efficacy rate of the combined group was higher than that of the laser group(95.24%vs.80.00%,P<0.05).There were no significant statistically differences in the incidence of transient flushing,local cutaneous redness,pigmentation and slight swelling between laser group and combined group(P>0.05).Conclusion The use of mesotherapy with tranexamic acid assisted fractional laser in the treatment of rosacea can improve the therapeutic effect as well as the cutaneous conditions of patients,and is a safe treatment option with high safety.