中药“酒行药势”理论的现代研究

Modern theoretic researches on"Liquor and Medicine"in Chinese Medicine

酒制是一种传统中药炮制工艺,酒行药势是中药炮制的重要理论。酒和药的“彼倡此和”使得药物经酒制后改变药性、引药上行、缓和药物苦寒之性、降低药物毒性、增强活血通络止痛、补肝肾及其他作用,从而实现减毒增效的目的。该文综述了中药酒制的历史考证、机制探究、研究趋势等,结合中药质量标志物及靶向制剂机制对酒制中药增效减毒的现代研究,为进一步验证、发扬“酒行药势”炮制理论及指导临床合理用药提供科学凭据。

Wine processing has been one kind of traditional Chinese medicine(TCM) processing technology and medicinal potential of wine remains an important theory of TCM processing. Wine and medicine may be applied for alleviating bitter cold, enhancing an activation of blood circulation, boost pain relief and tonify liver and kidneys to achieve the outcomes of minimizing toxicity and enhancing efficacy. The changes in composition and efficacy before and after wine preparation were explained thoroughly for confirming the scientific validity of concoction theory of wine processing. This review summarized the historical evidence, theoretical validations, mechanistic explorations and research trends of wine system. Modern researches have concentrated upon the efficacy and detoxification of wine system with the quality markers of TCM and the mechanism of targeted preparation to provide scientific evidence for further developing concoctional theory of "Liquor and Medicine" and offering guidance for clinical use of TCM.