贝伐珠单抗、呋喹替尼致高血压、肾病综合征1例

Hypertension and nephrotic syndrome induced by bevacizumab and fuquitinib:one case report

通过1份老年男性患者使用贝伐珠单抗、呋喹替尼引起高血压、肾病综合征的病例资料与相关文献进行回顾分析。患者使用贝伐珠单抗、呋喹替尼后出现血压升高达190/110 mmHg、大量蛋白尿(17.36 g·d^(-1)),血清白蛋白降至24.4 g·L^(-1),双下肢水肿,考虑为贝伐珠单抗、呋喹替尼所致高血压、继发性肾病综合征可能性大,经停用呋喹替尼、血液净化治疗与对症支持处理后有所好转。提示贝伐珠单抗、呋喹替尼可能会导致高血压、肾病综合征,临床使用该类药物时需警惕类似药物不良反应的发生。

Hypertension and nephrotic syndrome induced by bevacizumab and fuquitinib in an elderly male was analyzed with a review of the relevant literature. After dosing of bevacizumab and fuquitinib, there was an onset of elevated blood pressure(190/110 mmHg), massive proteinuria(17. 36 g·d^(-1)), lower level of serum albumin(24. 4 g·L^(-1)) and edema of both lower extremities. There was a high possibility of hypertension and secondary nephrotic syndrome due to bevacizumab and fuquitinib. The symptoms improved after a withdrawal of fuquinitinib, blood purification and symptomatic supports.