超声造影结合血清肠三叶因子对非小细胞肺癌诊断价值研究

Study on the Diagnostic Value of Contrast-Enhanced Ultrasound Combined with Serum Intestinal Trefoil Factor in Non-Small Cell Lung Cancer

目的:探讨超声造影结合血清肠三叶因子(ITF)对于非小细胞肺癌(NSCLC)的诊断价值。方法:纳入2021年1月-2023年6月在我院接受手术治疗的肺部占位患者130例作为研究对象。所有患者术前均接受超声造影检查及血清ITF检测。根据患者术后病理结果,分为NSCLC组(n=58)和肺部良性肿瘤组(n=72)。比较两组患者超声造影参数及血清ITF水平。绘制受试者工作特征曲线(ROC)分析超声造影参数、血清ITF及两者联合对NSCLC的诊断价值。结果:NSCLC组RT、TP、AT2和△AT均高于肺部良性肿瘤组(P<0.05)。NSCLC组血清ITF水平高于肺部良性肿瘤组(P<0.05)。超声造影参数行ROC曲线分析结果显示:曲线下面积(AUC)最大的为△AT,且当△AT≥3.14s时,其特异性为88.29%,对NSCLC具有较高的诊断价值。血清ITF行ROC曲线分析结果显示:AUC为0.735,且当血清ITF≥1073.82 pg/mL时,其特异性为81.06%,对NSCLC具有一定诊断价值。超声造影参数结合血清ITF行ROC曲线分析结果显示:AUC为0.916,其特异性为91.20%,对NSCLC具有最佳的诊断价值。结论:超声造影结合血清ITF对NSCLC具有较高的诊断价值,有助于肺部良恶性肿瘤的鉴别诊断,为患者的临床诊疗提供可靠的参考依据。

Objective:To investigate the diagnostic value of contrast-enhanced ultrasound combined with serum intestinal trefoil factor(ITF)in non-small cell lung cancer(NSCLC).Methods:From January 2021 to June 2023,130 patients with pulmonary space-occupying lesions who underwent surgical treatment in our hospital were included as the study subjects.All patients underwent contrast-enhanced ultrasonography and serum ITF detection before operation.According to the postoperative pathological results,the patients were divided into NSCLC group(n=58)and benign lung tumor group(n=72).Contrast-enhanced ultrasound parameters and serum ITF levels were compared between the two groups.The receiver operating characteristic curve(ROC)was drawn to analyze the diagnostic value of contrast-enhanced ultrasound parameters,serum ITF and their combination for NSCLC.Results:RT,TP,AT2 and△AT in NSCLC group were higher than those in benign lung tumor group(P<0.05).The level of serum ITF in NSCLC group was higher than that in benign lung tumor group(P<0.05).The results of ROC curve analysis of contrast-enhanced ultrasound parameters showed that the largest area under the curve(AUC)was△AT,and when△AT≥3.14s,its specificity was 88.29%,which had high diagnostic value for NSCLC.ROC curve analysis of serum ITF showed that AUC was 0.735,and when serum ITF≥1073.82 pg/mL,its specificity was 81.06%,which had certain diagnostic value for NSCLC.The ROC curve analysis of contrast-enhanced ultrasound parameters combined with serum ITF showed that the AUC was 0.916 and the specificity was 91.20%,which had the best diagnostic value for NSCLC.Conclusion:Contrast-enhanced ultrasound combined with serum ITF has a high diagnostic value for NSCLC,which is helpful for the differential diagnosis of benign and malignant lung tumors,and provides a reliable reference for the clinical diagnosis and treatment of patients.