左西孟旦对急性心肌梗死患者PCI治疗后心肌灌注和心电图指标的影响

Effects of Levosimendan on Myocardial Perfusion and Electrocardiogram Indexes in Patients with Acute Myocardial Infarction after PCI

目的:探讨左西孟旦对急性心肌梗死患者经皮冠状动脉介入(PCI)治疗后心肌灌注和心电图指标的影响。方法:选择2020年1月至2022年12月在我院接受治疗的113例急性心肌梗死患者PCI治疗患者,采用随机数表法分为试验组(n=57)和对照组(n=56)。对照组给予PCI治疗后氯吡格雷治疗,试验组加用左西孟旦治疗。比较两组临床疗效、心肌灌注分级、2 h内ST段回落幅度、Tp-e/QT、CI、LVEF、LVESD、LVEDD及并发症发生情况。结果:试验组治疗总有效率89.13%,较对照组71.11%高,(P<0.05);治疗后,两组心肌灌注分级水平均升高,试验组升高更为明显(P<0.05);试验组2 h内ST段回落幅度良好较对照组高(P<0.05),治疗后,两组Tp-e/QT水平均降低,试验组降低更为明显(P<0.05);治疗后,两组CI、LVEF水平均升高,试验组升高更为明显(P<0.05),两组LVESD、LVEDD水平均降低,试验组降低更为明显(P<0.05);治疗期间,不良反应主要有恶心、发热、再发心绞痛及心律失常,两组发生率比较(P>0.05)。结论:在急性心肌梗死患者PCI治疗中左西孟旦治疗有较好的效果,可有效改善患者心肌灌注和心电图指标水平。

Objective:To study Effects of levosimendan on myocardial perfusion and electrocardiogram indexes in patients with acute myocardial infarction after Percutaneous coronary intervention(PCI).Methods:113 patients with acute myocardial infarction who received PCI treatment in our hospital from January 2020 to December 2022 were selected and divided into experimental group(n=57)and control group(n=56)by random number table method.The control group was treated with clopidogrel after PCI,and the experimental group was treated with levosimendan.The clinical efficacy,myocardial perfusion grade,ST segment retreat within 2 h,Tp-e/QT,CI,LVEF,LVESD,LVEDD and the incidence of complications were compared between the two groups.Results:The total effective rate of the experimental group was 89.13%,higher than that of the control group 71.11%(P<0.05).After treatment,the myocardial perfusion grade level of both groups was increased,and the increase of experimental group was more obvious(P<0.05).The ST segment in test group was better than that in control group within 2 h(P<0.05).After treatment,the Tp-e/QT level in both groups was decreased,and the decrease in test group was more obvious(P<0.05).After treatment,CI and LVEF levels were increased in both groups,more significantly in experimental group(P<0.05);LVESD and LVEDD levels were decreased in both groups,more significantly in experimental group(P<0.05);During treatment,the main adverse reactions were nausea,fever,recurrent angina pectoris and arrhythmia,and the incidence rate was compared between the two groups(P>0.05).Conclusion:Levosimendan has a good effect in PCI treatment of patients with acute myocardial infarction,which can effectively improve the level of myocardial perfusion and electrocardiogram.