外周血血常规相关参数在急诊甲型流感病毒初筛阳性患儿中的应用价值分析

Analysis on Application Value of Peripheral Blood Routine Indicators in Children with Preliminary Positive Influenza A Virus Screening

目的:探究外周血血常规相关参数在急诊甲型流感病毒初筛阳性患儿中的应用价值。方法:回顾性收集2023年3月1日至2023年4月19日流感爆发期于西北妇女儿童医院儿科急诊就诊的378例甲型流感患儿作为研究对象,另选取同期于我院儿保科行健康体检的378例健康儿童为对照组,检测两组受试儿童白细胞计数(WBC)、中性粒细胞(Neu)、淋巴细胞(Lym)、单核细胞(Mon)、血小板计数(PLT)、血小板分布宽度(PDW)、中性粒细胞/淋巴细胞比值(NLR)、淋巴细胞/单核细胞比值(LMR)和血小板/淋巴细胞比值(PLR),应用ROC曲线判定外周血常规指标对不同年龄儿童发生甲型流感的预测效能。结果:在378例甲型流感患儿中,男童检出人数多于女童,幼儿期(月龄>12且≤36)和学龄前期(月龄>36且≤72)多于其他年龄段的患儿。研究组外周血中WBC、Lym、PLT和LMR显著低于对照组,同时Neu、Mon、PDW、NLR和PLR显著高于对照组(P<0.05)。不同年龄段的甲型流感患儿的血常规指标存在一定程度的差异(P<0.05),不同血常规指标对于不同年龄段儿童感染甲型流感均有较好的预测价值。结论:外周血常规指标在不同年龄段甲型流感患儿的早期筛查诊断中具有较高的应用价值,可为临床早期筛查、及早防控、降低感染率和死亡率提供一定的帮助。

Objective: To investigate the application value of peripheral blood routine indicators in children with preliminary positive influenza A virus screening. Methods: 378 children with influenza A admitted to our hospital from March 1st 2023 to April 19th2023 were collected as research group, another 378 healthy children were collected as control group, the peripheral blood routine indicators white blood cell(WBC), neutrophilic granulocyte(Neu), lymphocyte(Lym), monocyte(Mon), platelet count(PLT), platelet distribution width(PDW), NLR, LMR and PLR of two groups were detected, the predictive value of peripheral blood routine indicators for early screening diagnosis of influenza A in children with different ages were evaluated by ROC curve. Results: The detected number of boys was higher than girls of 378 cases, toddler stage(>12 and ≤36 months) and preschool stage(>36 and ≤72 months) children were more than other age stages. The WBC, Lym, PLT and LMR of research group were lower than control group, while Neu, Mon, PDW, NLR and PLR were higher(P<0.05). The peripheral blood routine indicators in children with different ages had certain extent difference s(P<0.05),different peripheral blood routine indicators had superior application values of children in different ages. Conclusion: Peripheral blood routine indicators show superior application values for early screening diagnosis of influenza A in children with different ages, which can provide certain help for clinical early diagnosis, early prevention and control, reducing infection rates and mortality.