丁苯酞联合阿替普酶对急性脑梗死患者血清IL-8、IL-10水平的影响

Effects of butylphthalide combined with alteplase on serum IL-8 and IL-10 levels in patients with acute cerebral infarction

目的研究丁苯酞联合阿替普酶对急性脑梗死患者血清白细胞介素-8(IL-8)、白细胞介素-10(IL-10)水平的影响。方法选取2020年1月至2021年1月我院收治的122例急性脑梗死患者为研究对象,按照随机数字表法将其分为对照组(n=61)和观察组(n=61)。对照组采用阿替普酶静脉溶栓治疗,观察组在此基础上联合丁苯酞治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的收缩期最大血流速度(Vs)、平均血流速度(Vm)高于对照组,阻力指数(RI)低于对照组(P<0.05)。治疗后,观察组的神经元特异性烯醇化酶(NSE)、IL-8水平低于对照组,6-酮-前列腺素F1α(6-K-PGF1α)、IL-10水平高于对照组(P<0.05)。治疗后,观察组的美国国立卫生研究院卒中量表(NIHSS)评分低于对照组,蒙特利尔认知功能评估量表(MoCA)评分高于对照组(P<0.05)。结论丁苯酞联合阿替普酶治疗急性脑梗死患者的效果显著,可改善颅内血流动力学,减轻炎症反应,提升神经功能及认知功能,值得临床推广与应用。

Objective To study the effects of butylphthalide combined with alteplase on serum interleukin-8(IL-8)and interleukin-10(IL-10)levels in patients with acute cerebral infarction.Methods A total of 122 patients with acute cerebral infarction admitted in our hospital from January 2020 to January 2021 were selected as the research objects and divided into control group(n=61)and observation group(n=61)according to the random number table method.The control group was treated with alteplase intravenous thrombolysis,and the observation group was treated with butylphthalide on this basis.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,maximum systolic blood flow velocity(Vs)and mean blood flow velocity(Vm)in the observation group were higher than those in the control group,and resistance index(RI)was lower than that in the control group(P<0.05).After treatment,the levels of neuron specific enolase(NSE)and IL-8 in the observation group were lower than those in the control group,and the levels of 6-keto-prostaglandin F1α(6-K-PGF1α)and IL-10 were higher than those in the control group(P<0.05).After treatment,the National Institute of Health Stroke Scale(NIHSS)score of the observation group was lower than that of the control group,and the Montreal Cognitive Assessment Scale(MoCA)score was higher than that of the control group(P<0.05).Conclusion Butylphthalide combined with alteplase has a significant effect in the treatment of patients with acute cerebral infarction.It can improve intracranial hemodynamics,reduce inflammatory response,and elevate neurological function and cognitive function.It is worthy of promotion and application in clinic.