中药抗病毒作用机制的研究进展

Research Progress on Antiviral Mechanism of Effects of Traditional Chinese Medicine Preparations against Viral Diseases

中药作为一种传统的药物,具有丰富的药理活性成分,对病毒感染具有显著的防治效果。特别是在我国新冠病毒感染的治疗中,抗病毒类中药制剂发挥了至关重要的作用。这些中药制剂以其独特的整体效应和多层次、多靶点、多通路的作用特点,有效抑制了病毒的复制和扩散,且其疗效不会受病毒变异而产生太大影响,对预防病毒感染展现出明显的优势。近年来对中药抗病毒作用机制的研究已取得了一些进展,但中药抗病毒作用机制仍存在许多尚待深入探讨的问题,比如中药抗病毒活性的物质基础、作用靶点及作用机理等。中药抗病毒有效成分的筛选及其药理药效的评价是今后研究的重要方向。本文通过深入查阅有关文献,以抗病毒作用机制为依据对具有抗病毒活性成分的中药制剂及其有效成分进行综述,以期为抗病毒中药制剂的研发提供理论依据,为临床应用抗病毒制剂提供参考。

As a traditional medicine,traditional Chinese medicine has rich pharmacological active ingredients and has significant prevention and control effect on viral infection.In particular,in the treatment of COVID-19 in China,antiviral drugs and traditional Chinese medicine preparations have played a vital role.These traditional Chinese medicine and its preparations with its unique overall effect and multi-level,multi-target,multiple pathway characteristics,effectively inhibit the replication of the virus and diffusion,and its curative effect is not affected by virus mutation and too much,to prevent virus infection show obvious advantages,in recent years,the study of Chinese medicine antiviral mechanism has made some progress,Chinese medicine antiviral mechanism there still has many problems to be discussed,such as TCM antiviral activity of substance basis,targets and mechanism of action,etc.The screening of effective TCM antiviral ingredients and the evaluation of their pharmacological efficacy are important directions for future research.Through in-depth review of relevant literature books,this paper summarizes the Chinese medicine preparations with antiviral active ingredients based on the antiviral mechanism of action,in order to provide theoretical basis for the research and development of antiviral Chinese medicine preparations and provide reference for the clinical application of antiviral preparations.