五味消毒饮联合抗生素治疗创伤性骨髓炎临床研究

Clinical Study on Wuwei Xiaodu Decoction Combined with Antibiotic in the Treatment of Traumatic Osteomyelitis

目的:观察五味消毒饮联合抗生素治疗创伤性骨髓炎的疗效。方法:选取80例创伤性骨髓炎患者,按随机数字表法分为对照组38例及联合组42例。对照组采用抗生素治疗,联合组采用五味消毒饮联合抗生素治疗。比较2组临床疗效,比较2组治疗前后免疫指标值、临床指标值(抗生素使用时间、拔管时间)、生化指标值[白细胞计数、中性粒细胞、血沉、C-反应蛋白(CRP)、降钙素原(PCT)]、疼痛视觉模拟评分法(VAS)评分的变化。结果:联合组临床疗效总有效率为95.24%,对照组为76.32%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组CD4^(+)、CD4^(+)/CD8^(+)指标值均较治疗前升高(P<0.05),CD8^(+)指标值均较治疗前下降(P<0.05);联合组CD4^(+)、CD4^(+)/CD8^(+)指标值均高于对照组(P<0.05),CD8^(+)指标值低于对照组(P<0.05)。联合组抗生素使用时间、拔管时间均短于对照组,差异均有统计学意义(P<0.05)。治疗后,2组白细胞、中性粒细胞、血沉、CRP、PCT指标值均较治疗前下降(P<0.05),联合组上述5项指标值均低于对照组(P<0.05)。治疗后,2组VAS评分均较治疗前下降(P<0.05),联合组VAS评分低于对照组(P<0.05)。结论:五味消毒饮联合抗生素治疗创伤性骨髓炎疗效确切,可调节机体免疫功能及生理状态,缓解疼痛症状。

Objective:To observe the curative effect of Wuwei Xiaodu Decoction combined with antibiotic in the treatment of traumatic osteomyelitis.Methods:A total of 80 cases of patients with traumatic osteomyelitis were selected and divided into the control group and the combination group according to the random number table method,with 38 and 42 cases in each group respectively.The control group was treated with antibiotic,and the combination group was treated with Wuwei Xiaodu Decoction combined with antibiotic.Clinical effects were compared between the two groups.The changes in immune indicators,clinical indicators(antibiotic using time and extubation time),biochemical indicators[white blood cells,neutrophils,erythrocyte sedimentation rate,C-reactive protein(CRP)and procal-citonin(PCT)],and scores of Visual Analogue Scale(VAS)for pain evaluation were compared between the two groups before and after treatment.Results:The total clinical effective rate was 95.24%in the combination group and 76.32%in the control group,the difference being significant(P<0.05).After treatment,CD4^(+)and CD4^(+)/CD8^(+)in the two groups were increased when compared with those before treatment(P<0.05),and CD8^(+)was declined when compared with that before treatment(P<0.05);CD4^(+)and CD4^(+)/CD8^(+)in the combination group were higher than those in the control group(P<0.05),and CD8^(+)in the combination group was lower than that in the control group(P<0.05).Antibiotic using time and extubation time in the combination group were shorter than those in the control group,the difference being significant(P<0.05).After treatment,the indicators including white blood cells,neutrophils,erythrocyte sedimentation rate,CRP,and PCT in the two groups were reduced when compared with those before treatment(P<0.05),and the indicators above in the combination group were lower than those in the control group(P<0.05).After treatment,VAS scores in the two groups were decreased when compared with those before treatment(P<0.05),and VAS score in the combination group was lower than that in the control group(P<0.05).Conclusion:Wuwei Xiaodu Decoction combined with antibiotic has a definite curative effect in the treatment of traumatic osteomyelitis,which can regulate the body's immune function and physiological state and relieve pain.