大黄芒硝散外敷联合穴位贴敷治疗急性胰腺炎疗效观察及对血清淀粉酶、炎症因子水平的影响

Observation on Curative Effect of External Application of Dahuang Mangxiao Powder Combined with Point Application on Acute Pancreatitis and Its Effect on Levels of Serum Amylase and Inflammatory Factors

目的:观察大黄芒硝散外敷联合穴位贴敷治疗肝郁气滞型急性胰腺炎(AP)的临床疗效及对血清淀粉酶(AMS)、炎症因子[白细胞介素-6 (IL-6)、C-反应蛋白(CRP)]水平的影响。方法:选取96例肝郁气滞型AP患者,按随机数字表法分为试验组和对照组各48例。对照组在常规治疗的基础上给予生长抑素治疗,试验组在对照组基础上加用大黄芒硝散外敷联合穴位贴敷治疗。观察2组临床疗效及治疗期间不良反应发生率,以及治疗前后症状消失时间、胃肠功能恢复时间、血清AMS、IL-6、CRP水平变化。结果:治疗后,试验组总有效率为95.83%,对照组为77.08%,2组比较,差异有统计学意义(P<0.05)。治疗后,试验组腹胀腹痛、恶心、发热消失时间均短于对照组(P<0.05)。治疗后,试验组肠鸣音、胃肠蠕动、自主排气及排便恢复时间均短于对照组(P<0.05)。治疗后,2组血清AMS、IL-6、CRP水平均较治疗前降低(P<0.05),且试验组AMS、IL-6、CRP水平均低于对照组(P<0.05)。试验组不良反应发生率为8.33%,对照组为16.67%,2组比较,差异无统计学意义(P>0.05)。结论:大黄芒硝散外敷联合穴位贴敷治疗肝郁气滞型AP疗效良好,能够下调炎症因子水平,改善胃肠功能,促进临床症状缓解。

Objective:To observe the clinical effect of the therapy of external application of Dahuang Mangxiao Powder combined with point application on acute pancreatitis(AP)of liver constraint and qi stagnation type and its effect on levels of serum amylase(AMS)and inflammatory factors[interleukin-6(IL-6)and C-reactive protein(CRP)].Methods:A total of 96 AP patients of liver constraint and qi stagnation type were selected and divided into the trial group and the control group according to the random number table method,with 48 cases in each group.The control group was additionally treated with Somatostatin except for routine treatment,and the trial group was additionally treated with external application of Dahuang Mangxiao Powder combined with point application based on the treatment of the control group.The clinical effects in the two groups,the incidence of adverse reactions during the treatment,and the changes in disappearance time of symptoms,recovery time of gastrointestinal function,and levels of serum AMS,IL-6 and CRP before and after treatment were observed.Results:After treatment,the total effective rate was 95.83%in the trial group,and 77.08%in the control group,the difference being significant(P<0.05).After treatment,the disappearance time of abdominal distention and pain,nausea and fever in the trial group was respectively shorter than that in the control group(P<0.05).After treatment,the recovery time of gurgling sound,gastrointestinal peristalsis,spontaneous farting and defecation was obviously shorter than that in the control group(P<0.05).After treatment,the levels of serum AMS,IL-6 and CRP in both groups were reduced when compared with those before treatment(P<0.05),and the above three levels in the trial group were lower than those in the control group(P<0.05).The incidence of adverse reactions was 8.33%in the trial group and 16.67%in the control group,there being no significance in the difference(P>0.05).Conclusion:The therapy of external application of Dahuang Mangxiao Powder combined with point application has a great curative effect on AP of liver constraint and qi stagnation type,which can down-regulate the levels of inflammatory factors,improve the gastrointestinal function with great function,and promote the mitigation of clinical symptoms.