2000至2023年雷公藤多苷研究热点及趋势的可视化分析

Visual Analysis of Research Hotspots and Trends of Tripterygium Glycosides from 2000 to 2023

[目的]梳理雷公藤多苷(tripterygium glycosides,TG)的研究现状与热点,为今后TG的深入研究与临床推广提供参考依据。[方法]计算机检索中国知网(China National Knowledge Internet,CNKI)、万方数据库、中文科技期刊数据库(China Science and Technology Journal Database,VIP)、中国生物医学文献数据库(China Biology Medicine disc,CBM)中2000年1月至2023年6月关于TG的文献,使用NoteExpress软件进行数据合并、查重及清洗,采用Excel构建年度发文量折线图,运用VOSviewer 1.6.13软件和CiteSpace 6.2 R2软件对其作者、机构及关键词进行可视化分析,绘制相关图谱。[结果]共纳入1 752篇文献,2008年以来,发文量阶段性增长后,近几年有下降趋势;共涉及作者4 186位,其中核心作者75位,形成了以丁樱、李振彬、林娜、崔瑞琴、陈卫东等为代表的合作团队;主要发文机构为河南中医药大学第一附属医院和河南中医药大学,其次为北京中医药大学东直门医院,研究机构相对独立分散,多是中医类院校与其附属医院的合作,跨地区的合作较少。关键词共现网络图共形成了6个聚类,研究热点主要是TG联合用药应用于糖尿病肾病、紫癜性肾炎及肾病综合征等肾脏疾病,类风湿关节炎等风湿免疫性疾病及皮肤黏膜类疾病的临床研究,以及TG毒副作用的实验研究。近几年突现的关键词有皮炎湿疹、咪唑斯汀、炎症因子、免疫功能、他克莫司等。[结论]TG在肾脏疾病、风湿免疫性疾病等领域的临床疗效及其安全性研究是研究热点,皮炎湿疹等皮肤黏膜类疾病、TG作用机制及炎症因子等领域可能是未来的研究趋势。各团队间仍需加强合作,加强TG作用机制的基础研究,并探索有效的配伍减毒方式,为今后TG的临床应用提供参考依据。

[Objective Objective]To summarize the research status and hotspots of tripterygium glycosides(TG),to provide reference basis for future in depth research and clinical promotion of TG.[Methods Methods]Computer retrieval of literature related to TG from January 2000 to June 2023 was conducted using the China National Knowledge Internet(CNKI),Wanfang Data,China Science and Technology Journal Database(VIP),China Biology Medicine disc(CBM).Use NoteExpress software to merge,duplicate check,and clean data,and use Excel software to construct an annual publication volume line chart.Visualize and analyze the author,organization,and keywords using VOSviewer 1.6.13 and CiteSpace 6.2 R 2 software,and draw relevant graphs.[Results Results]A total of 1752 articles were included.Since 2008,the number of publications has shown a decreasing trend in recent years after a gradual increase.A total of 4186 authors were involved,including 75 core authors,forming a collaborative team represented by DING Ying,LI Zhenbin,LIN Na,CUI Ruiqin,CHEN Weidong and others.The main publishing institutions were the First Affiliated Hospital of He’nan University of Chinese Medicine and He’nan University of Chinese Medicine,followed by Dongzhimen Hospital of Beijing University of Chinese Medicine.The research institutions were relatively independent and scattered,mostly through cooperation between traditional Chinese medicine universities and their affiliated hospitals,with less cross regional cooperation.A total of six clusters of key words had been formed in the network diagram.The research focuses were mainly summarized as the clinical research on the application of TG combination drugs in kidney diseases such as diabetes nephropathy,purpura nephritis and nephrotic syndrome,rheumatic immune diseases such as rheumatoid arthritis,skin and mucosal diseases,and the experimental research on the toxicity and side effects of TG.In recent years,keywords that had emerged included dermatitis,eczema,mizolastin,inflammatory factors,immune function,tacrolimus,and so on.[Conclusion Conclusion]The clinical efficacy and safety research of TG in kidney diseases,rheumatic immune diseases and other fields are hot topics.Dermatitis,eczema,and other skin and mucosal diseases,as well as the mechanism of TG action and inflammatory factors,may be the future research trends.There is still a need to strengthen cooperation among teams,strengthen basic research on the mechanism of TG action,and explore effective compatibility and detoxification methods,providing reference basis for the clinical application of TG in the future.