改良配方紫云膏治疗婴幼儿蚊虫叮咬后皮炎临床效果研究

Clinical Efficacy of Improved Formula Ziyun Ointment in Treating Dermatitis after Mosquito Bites in Infants and Young Children

目的:研究改良配方紫云膏治疗婴幼儿蚊虫叮咬后皮炎效果观察。方法:2021年6月—2023年9月在山东省慢性病医院和青岛市第八人民医院的住院患者、中医门诊患者、儿保门诊患者以及夏秋季节幼儿园查体人群中筛查出婴幼儿蚊虫叮咬性皮炎患者50例作为研究对象,以研究对象的蚊虫叮咬性皮炎作为样本,建议患者及家属采取A、B、C3种方法治疗蚊虫叮咬性皮炎。其中A方法为采用生大蒜横断面汁液外用擦拭,B方法为采用醋酸地塞米松乳膏(皮炎平)外用擦拭,C方法为采用我院改良配方紫云膏外用擦拭。观察并记录涂药后患者蚊虫叮咬后皮炎的痒痛、红肿症状的缓解情况,最终收集皮炎样本326例,其中A方法(A组)样本98例,B方法(B组)样本106例,C方法(C组)样本122例。根据统计数据对3种方法的效果进行统计学分析。结果:3组样本蚊虫叮咬性皮炎的痒痛、红肿症状均改善,但C组患者皮肤刺激较轻,症状缓解快,两两比较具有统计学意义。结论:改良配方紫云膏可以明显改善婴幼儿蚊虫叮咬后皮炎的痒痛、红肿症状,且不良反应小,大众接受度高,可以推广。

Objective: To observe the effect of the modified formula Ziyun ointment in the treatment of dermatitis af-ter mosquito bites in infants and young children. Methods: From June 2021 to September 2023, 50 cases of infantile and young children with mosquito bite dermatitis were screened from inpatients, TCM outpatients, pediatric outpatients, and kindergarten physical examinations in summer and autumn in Shandong Chronic Disease Hospital and Qingdao Eighth People’s Hospital as research subjects. The mosquito bite dermatitis of the research subjects was used as a sample. Patients and their families were advised to use A, B, and C methods to treat mosquito bite dermatitis. Method A is to wipe the juice of the cross section of raw garlic externally, method B is to wipe the dexamethasone acetate cream (Pi-yanping) externally, and method C is to wipe the modified formula Ziyun ointment of our hospital externally. The relief of itching, pain, redness and swelling symptoms of post-insect bite dermatitis in patients after applying the medicine was observed and recorded. Finally, 326 dermatitis samples were collected, including 98 samples of method A (group A), 106 samples of method B (group B), and 122 samples of method C (group C). The effects of the three methods were sta-tistically analyzed based on statistical data. Results: The itching, pain, and redness and swelling symptoms of post-in-sect bite dermatitis in the three groups of samples were improved, but the skin irritation of group C patients was milder and the symptoms were relieved faster. The pairwise comparison was statistically significant. Conclusion: The improved formula Ziyun ointment can significantly improve the itching, pain, and redness and swelling symptoms of post-insect bite dermatitis in infants and young children, with few side effects and high public acceptance, and can be promoted.