肿瘤耐药性的研究进展

Research Progress on Drug Resistance of Tumors

癌症作为严重威胁生命的疾病之一,是人类第二大死因。目前治疗癌症的主要手段为手术、化疗和放疗等,均需要配合使用抗肿瘤药物,然而肿瘤细胞会对抗癌药物产生耐药性,从而使药物的治疗效果达不到理想状态。耐药性作为造成临床化疗失败的主要原因,一直以来受到广泛关注。因此,本研究综述了肿瘤多种耐药机制,包括肿瘤微环境、病毒因素、细胞物质转运、药物代谢酶等,以期为抗肿瘤药物的研发及癌症耐药性的研究提供参考。可以推测未来肿瘤的治疗方案将包括使用不同类型的药物,针对多药耐药性特定机制的特定弱点等联合疗法。通过逆转癌细胞耐药性的新药将提高化疗的效率,为目前无法治愈的肿瘤患者提供机会。

As one of the serious life-threatening diseases,cancer is the second leading cause of death in human beings.At present,the main methods of cancer treatment are surgery,chemotherapy and radiotherapy,all of which require the use of anti-tumor drugs,but tumor cells will become resistant to antitumor drugs,so that pharmacotherapy cannot reach the ideal effect.Drug resistance,as the main cause of failure of clinical chemotherapy,has been widely concerned.Therefore,this study reviewed the mechanisms of drug resistance of tumors,including tumor microenvironment,viral factors,cellular material transport,and drug metabolism enzymes,in order to pro⁃vide a reference for the development of anti-tumor drugs and the study of cancer drug resistance.It can be speculated that future treat⁃ment options for tumors will include the use of different types of drugs,targeting specific weaknesses in specific mechanisms of multidrug resistance,etc.It is necessary to further study the mechanism of cancer resistance and design new potential chemotherapy drugs.New drugs that reverse drug resistance in cancer cells will improve the efficiency of chemotherapy and provide opportunities for patients with tumors that are currently incurable.