摘要
In addition to their canonical roles in biosynthetic pathways,metabolites can be active participants in oncogenic signal-ling,but our understanding of these signalling mechanisms is incomplete.In a recent article published in Cell,Mossmann et al.find a novel signalling role for accumulated arginine in hepato-cellular carcinoma(HCC)mediated by the RNA splicing factor and transcriptional modifier RNA-binding protein 39(RBM39).
基金
support from the National Institute of General Medical Sciences,R35GM147118 to LS and PHS NRSA T32GM007270 to DS.
