摘要
Autophagic degradation of membrane-bound organelles such as the endoplasmic reticulum(ER),mitochondria,and peroxisomes is mediated by a family of receptors.In a recent study,Hickey et al.revealed that autophagy triggered by nutrient stress,previously thought to degrade bulk cytoplasmic contents,prioritizes the ER and Golgi as cargoes for degradation.They further demonstrated that Yip1 domain family member 3(YIPF3)and YIPF4 act as receptors to mediate the delivery of Golgi to the lysosomes for Golgi remodelling during nutrient stress and also neuronal differentiation.
