微重力对肝脏和结肠作用的研究进展

Research progress of microgravity effect on liver and colon

随着我国航天技术的日益成熟与进步,航天员能够在空间站停留更长时间,完成更为复杂的空间实验和任务。在太空微重力环境下,失重不可避免地会对航天员的消化系统产生影响,尤其是肝脏和结肠,存在较多的生理和病理改变。微重力可对肝脏代谢功能、细胞增殖分化、氧化应激反应以及炎症因子水平产生影响。微重力可破坏结肠的肠道屏障、肠道菌群和微生态、肠道免疫以及肠—肝轴。然而,目前关于微重力对肝脏、结肠影响的研究尚未完全清楚,且对二者的病理改变缺乏可靠的诊断指标。因此,为探寻微重力对肝脏及结肠的损伤机制,保障宇航员消化系统健康,本文围绕微重力对肝脏、结肠影响的研究进展进行综述。

With the increasing maturity and progress of China’s space technology,astronauts can stay longer in the space station and complete more complex space experiments and tasks.In the Microgravity(MG)environment of space,the digestive system of astronauts is inevitably affected,especially the liver and colon,and there are many physiological and pathological changes.MG can affect liver metabolic function,cell proliferation and differentiation,oxidative stress response and inflammatory factor levels.MG can disrupt the intestinal barrier of the colon,intestinal flora and microecology,intestinal immunity,and the gut-liver axis.However,the existing studies on the effects of MG on liver and colon are not completely clear,and there is a lack of reliable diagnostic indicators for the pathological changes of both.Therefore,in order to explore the damage mechanism of MG on liver and colon and ensure the digestive system health of astronauts,this paper reviews the research progress on the effects of MG on liver and colon.