Ⅰ型干扰素在细菌性肺炎发生发展中的作用机制研究进展

Progress on Mechanisms of TypeⅠInterferon in Occurrence and Development of Bacterial Pneumonia

细菌性肺炎是免疫功能受损的人和哺乳动物临床上最常见的感染性肺炎,常表现为肺实质性急性炎症,引起人和动物的高发病率和病死率。Ⅰ型干扰素在细菌感染的反应中发挥着关键作用,但在不同的细菌感染中,Ⅰ型干扰素对宿主产生有益或有害的作用;在一些细菌感染过程中,Ⅰ型干扰素对宿主产生双重作用。论文综述了Ⅰ型干扰素在细菌性肺炎中的研究进展,重点阐述Ⅰ型干扰素在不同细菌性肺炎中发挥的作用及机制,为细菌性肺炎的防治提供理论依据。

Bacterial pneumonia is the most common clinical infectious pneumonia in human and mammals with impaired immune function,it is often manifested as acute inflammation of lung parenchyma,causing high morbidity and mortality in human and animals.TypeⅠinterferon plays a critical role in the response to bacterial infections,but it exhibits beneficial or harmful effects on hosts in different bacterial infections.In some bacterial infections,typeⅠinterferon shows a dual effect on hosts.The paper reviews the research progress on typeⅠinterferon in bacterial pneumonia,focusing on the role and mechanisms of typeⅠinterferon in different bacterial pneumonia.This review provides theoretical basis and new ideas for the prevention and control of bacterial pneumonia.