TyG指数、血清Gal-3、HDAC3与非瓣膜性心房颤动患者缺血性脑卒中发生风险的相关性分析

Correlation Analysis of TyG Index,Serum Gal-3,HDAC3 and the Risk of Cerebral Ischemic Stroke in Patients with Non-Valvular Atrial Fibrillation

目的:探讨甘油三酯葡萄糖(TyG)指数、血清半乳糖凝集素3(Gal-3)、组蛋白去乙酰化酶3(HDAC3)与非瓣膜性心房颤动(NVAF)患者缺血性脑卒中(CIS)发生风险的相关性。方法:选择2022年1月至2022年9月武汉科技大学附属华润武钢总医院收治的NVAF患者347例为研究对象,所有患者均随访1年,根据随访期间是否发生CIS分为CIS组和非CIS组。采用酶联免疫吸附法检测血清Gal-3、HDAC3水平,并计算TyG指数。采用多因素Logistics回归分析NVAF患者发生CIS的影响因素,采用受试者工作特征(ROC)曲线分析TyG指数及血清Gal-3、HDAC3对NVAF发生CIS的预测价值。结果:随访1年,NVAF患者CIS发生率为22.77%(79/347)。CIS组TyG指数、血清Gal-3、HDAC3水平高于非CIS组(P<0.05)。多因素Logistics回归分析显示,CHA2DS2-VASC评分、左心房内径(LAD)、TyG指数、Gal-3、HDAC3升高是NVAF患者发生CIS的独立危险因素(P<0.05),LVEF升高是NVAF患者发生CIS的保护因素(P<0.05)。TyG指数、Gal-3、HDAC3预测NVAF发生CIS的曲线下面积(AUC)分别为0.631、0.790、0.769,联合预测的AUC为0.918。结论:TyG指数、血清Gal-3和HDAC3升高是NVAF患者发生CIS的独立危险因素,TyG指数、血清Gal-3和HDAC3联合检测对NVAF患者发生CIS风险具有较高的预测价值。

Objective:To investigate the correlation between triglyceride glucose(TyG)index,serum galectin-3(Gal-3),histone deacetylase 3(HDAC3)and the risk of cerebral ischemic stroke(CIS)in patients with non-valvular atrial fibrillation(NVAF).Methods:347 NVAF patients admitted to China Resources WISCO General Hospital Affiliated to Wuhan University of Science and Technology from January 2022 to September 2022 were selected as research objects,all patients were followed up for 1 year,patients were divided into CIS group and non-CIS group according to whether CIS occurred during the follow-up period.Serum Gal-3 and HDAC3 levels were detected by enzyme-linked immunosorbent assay,and TyG index was calculated.The influencing factors of CIS in NVAF patients were analyzed by multivariate Logistics regression analysis,the predictive value of TyG index and serum Gal-3 and HDAC3 for CIS in NVAF patients were analyzed by receiver operating characteristic(ROC)curve.Results:After 1 year of follow-up,the incidence of CIS in NVAF patients was 22.77%(79/347).The TyG index,serum Gal-3 and HDAC3 levels in CIS group were higher than those in non-CIS group(P<0.05).Multivariate Logistics regression analysis showed that,the elevated of CHA2DS2-VASC score,left atrial dimension(LAD),TyG index,Gal-3 and HDAC3 were independent risk factors for CIS in NVAF patients(P<0.05),and elevated LVEF was protective factor for CIS in NVAF patients(P<0.05).The area under the curve(AUC)of TyG index,Gal-3 and HDAC3 in predicting CIS in NVAF was 0.631,0.790 and 0.769 respectively,and the AUC of combined prediction was 0.918.Conclusion:The increase of TyG index,serum Gal-3 and HDAC3 are independent risk factors for CIS in NVAF patients,the combine detection of TyG index,serum Gal-3and HDAC3 has a high predictive value for CIS risk in NVAF patients.