荆花胃康胶丸抗幽门螺杆菌的机制研究进展

Research progress of mechanism about Jinghua Weikang capsule against Helicobacter pylori

幽门螺杆菌(Helicobacter pylori,HP)是对人体健康造成严重威胁的一种细菌,全球感染率高,且耐药性高。荆花胃康胶丸在抗HP治疗方面取得了一定的临床效果,但其作用机制不详。荆花胃康胶丸主要通过影响NF-κB信号通路发挥抗HP作用;抑制HP生物膜的形成来提升抗生素的作用效率,同时还可降低抗生素的最低抑菌浓度,协同抗生素根除HP并逆转抗生素的耐药性;可改善HP感染后的肠道菌群结构,使有益菌群丰度增加,有害菌群数量减少;还能修复HP感染后损伤的胃黏膜,使胃黏膜上皮细胞形态恢复正常。本文对荆花胃康胶丸抗HP的作用机制进行综述。

Helicobacter pylori(HP)is a kind of bacteria that plays a serious threat to human health in the world,with a high global infection rate and high drug resistance.Jinghua Weikang capsule has got certain clinical effect in the treatment of HP,but its mechanism is still unknown.The results showed that Jinghua Weikang capsule anti-HP mainly by affecting NF-κB signaling pathway.It can inhibit the formation of HP biofilm then improve the efficiency of antibiotics,also can reduce the minimum inhibitory concentration of antibiotics,and cooperate with antibiotics to eradicate HP and reverse antibiotic resistance.It can also improve the intestinal flora structure after HP infected,increase the abundance of beneficial flora and decrease the number of harmful flora.It can also repair the damaged gastric mucosa after HP infected and restore the morphology of gastric mucosal epithelial cells to normal.In this paper,we will review the mechanism of Jinghua Weikang capsules against HP in detail.