肺再生中不同细胞的角色

Roles of different cells in lung regeneration

未受侵扰的肺高度静止, 细胞更新水平低。然而, 肺在受损后显示出广泛的再生能力, 常驻祖细胞群重新进入细胞周期并分化以促进修复。由于肺组织结构及细胞组成的复杂性, 位于不同区域的肺细胞表现出不同的再生策略。因此, 深入了解不同类型细胞在损伤, 修复和再生中的相互作用有助于全面认识肺再生的发生过程。本文针对肺损伤后参与再生的不同类型的细胞的作用及机制进行综述, 以启发临床医师依据不同细胞的再生特性探索出新的肺再生干预手段为治疗各种呼吸系统疾病提供新思路。

Uninvaded lungs are highly quiescent with a low level of cell renewal.However,lung tissues show extensive regenerative capacity after damage,with resident progenitor cell populations re-entering cell cycle and differentiating to facilitate repairing.Due to a great complexity of lung tissue structures and cellular compositions,lung cells exhibit different regenerative strategies in different regions.Therefore an in-depth understanding of interactions between different cell types in injury,repair and regeneration may contribute to a comprehensive understanding of how lung regeneration occurs.This review summarized the roles and mechanisms of different types of cells involved in regeneration after lung injury to inspire clinicians to explore new lung regeneration interventions based upon the regenerative properties of different cells to provide novel treatments of various respiratory diseases.