FAR联合TyG对急性心肌梗死患者PCI术后远期不良事件的预测价值

Predictive value of FAR and TyG for long-term adverse events after PCI in patients with acute myocardial infarction

目的研究纤维蛋白原与白蛋白比值(FAR)联合甘油三酯葡萄糖乘积(TyG)对急性心肌梗死患者远期不良事件的预后价值。方法选取2019年1月至2020年1月在喀什地区第二人民医院行经皮冠状动脉介入(PCI)治疗的急性心肌梗死患者325例作为研究对象。随访1年,根据患者有无不良心血管事件(MACE)发生,将其分为研究组(n=30)与对照组(n=295),详细记录患者病历资料如血脂指标、心功能指标等。采用多因素Cox回归分析研究影响急性心肌梗死患者MACE发生的危险因素。采用受试者工作特征(ROC)曲线研究FAR和TyG对预测急性心肌梗死患者MACE发生的预测价值。结果研究组FAR、TyG高于对照组,差异有统计学意义(P<0.05)。多因素Cox回归分析结果显示,FAR升高、TyG升高是急性心肌梗死患者MACE发生的独立危险因素(P<0.05)。ROC曲线结果显示,TyG≥7.943合并FAR≥0.086的患者预后比TyG<7.943合并FAR≥0.086、TyG≥7.943合并FAR<0.086、TyG<7.943合并FAR<0.086的患者差,差异有统计学意义(P<0.05)。结论患者外周血FAR及TyG升高与急性心肌梗死的预后有关,早期联合检测FAR和TyG对于评估急性心肌梗死患者的预后具有指导意义。

Objective To investigate the prognostic value of fibrinogen to albumin ratio(FAR)combined with triglyceride glucose product(TyG)on long-term adverse events in the patients with acute myocardial infarction.Methods A total of 325 patients with acute myocardial infarction treated by percutaneous coronary intervention(PCI)in the Second People’s Hospital of Kashi Prefecture from January 2019 to January 2020 were selected as the study subjects.The patients were followed up for 1 year and divided into the study group(n=30)and control group(n=295)according to whether or not the major adverse cardiovascular events(MACE)occurring.The medical case records of the patients such as blood lipid indexes and cardiac function indexes were recorded in detail.The multivariate Cox regression was used to analyze the risk factors affecting MACE occurrence in the patients with acute myocardial infarction.The receiver operating characteristic(ROC)curve was used to study the predictive value of FAR and TyG for the occurrence of MACE in the patients with acute myocardial infarction.Results The levels of FAR and TyG in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).The multivariate Cox regression analysis results showed that the FAR increase and TyG score increase were the independent risk factors for MACE occurrence in the patients with acute myocardial infarction(P<0.05).The ROC curve results showed that the prognosis in the patients with TyG≥7.943 and FAR≥0.086 was poorer than those with TyG<7.943 and FAR≥0.086,TyG≥7.943 and FAR<0.086,and TyG<7.943 and FAR<0.086,and the differences were statistically significant(P<0.05).Conclusion The increase of peripheral blood FAR and TyG is closely related to the prognosis of acute myocardial infarction.Early combined detection of FAR and TyG has the guidance significance in evaluating the prognosis of the patients with acute myocardial infarction.