lncRNA CHRF与NT-proBNP对急性缺血性脑卒中患者并发脑心综合征的预测价值

Predictive value of lncRNA CHRF and NT-proBNP in complicating cerebral-cardiac syndrome in patients with acute ischemic stroke

目的探讨长链非编码RNA心脏肥大相关因子(lncRNA CHRF)与N末端B型利钠肽原(NT-proBNP)对急性缺血性脑卒中(AIS)患者并发脑心综合征(CCS)的预测价值。方法选取2021年11月至2023年10月该院收治的AIS患者121例为研究对象,按住院期间是否并发CCS分为CCS组(n=49)与无CCS组(n=72),比较两组临床指标及lncRNA CHRF、NT-proBNP水平。采用Pearson进行相关性分析,多因素logistic回归分析AIS并发CCS的影响因素,绘制受试者工作特征(ROC)曲线分析相关指标的预测价值。结果CCS组年龄、血肌酐、超敏C反应蛋白(hs-CRP)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)、lncRNA CHRF、NT-proBNP水平高于无CCS组(P<0.05),左心室射血分数(LVEF)低于无CCS组(P<0.05)。相关性分析显示,AIS并发CCS患者的lncRNA CHRF与NT-proBNP水平呈正相关(P=0.040);lncRNA CHRF、NT-proBNP水平与CK-MB、cTnI、hs-CRP水平均呈正相关(P<0.05),与LVEF呈负相关(P<0.05)。多因素logistic回归分析显示,LVEF降低、lncRNA CHRF升高、NT-proBNP升高是AIS患者并发CCS的独立危险因素(P<0.05)。ROC曲线分析显示,lncRNA CHRF、NT-proBNP单独及联合的曲线下面积(AUC)分别为0.673、0.711、0.850。结论AIS患者并发CCS的lncRNA CHRF、NT-proBNP明显升高,二者联合检测有较高的预测价值。

Objective To investigate the predictive value of long non-coding RNA cardiac hypertrophy-related factor(lncRNA CHRF)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)in complicating cerebral-cardiac syndrome(CCS)in the patients with acute ischemic stroke(AIS).Methods A total of 121 patients with AIS admitted and treated in this hospital from November 2021 to October 2023 were selected as the study subjects and divided into the CCS group(n=49)and non-CCS group(n=72)according to whether or not complicating CCS during hospitalization.The clinical indicators,lncRNA CHRF and NT-proBNP levels were compared between the two groups.Pearson was adopted to conduct the correlation analysis.The multivariate Logistic regression was used to analyze the independent influencing factors of AIS complicating CCS.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of the related indicators.Results The age,serum creatinine,hypersensitive C reactive protein(hs-CRP),creatine kinase isoenzymes MB(CK-MB),cardiac troponin I(cTnI),lncRNA CHRF and NT-proBNP in the CCS group were higher than those in the non-CCS group(P<0.05),and left ventricular ejection fraction(LVEF)was lower than that in the non-CCS group(P<0.05).The correlation analysis showed that lncRNA CHRF in the patients with AIS complicating CCS was positively correlated with NT-proBNP(P=0.040).The lncRNA CHRF and NT-proBNP levels were positively correlated with CK-MB,cTnI and hs-CRP levels(P<0.05),and negatively correlated with LVEF(P<0.05).The multivariate logistic regression analysis showed that the decrease of LVEF,increase of lncRNA CHRF and NT-proBNP were the independent risk factors for complicating CCS in the patients with AIS(P<0.05).The ROC curve analysis showed that the area under the curve(AUC)of lncRNA CHRF and NT-proBNP alone and combination were 0.673,0.711 and 0.850 respectively.Conclusion The lncRNA CHRF and NT-proBNP levels are significantly increased in the patients with AIS complicating CCS,and their combined detection has high predictive value.