丁酸钠在结直肠癌细胞凋亡中的作用机制研究进展

Research progress on action mechanism of sodium butyrate in apoptosis of colorectal cancer cells

丁酸钠是膳食纤维在肠道微生物的作用下产生的一种四碳短链脂肪酸(SCFAs)钠盐,其可为肠道上皮细胞提供能量,在保持肠道上皮细胞的完整性、抑制肠道炎症和肿瘤等方面有着重要的作用。近年来,较多研究指出丁酸钠可以通过抑制组蛋白去乙酰化酶活性、半胱氨酸蛋白酶介导和内质网应激等多种方式介导结直肠癌细胞凋亡,提示丁酸钠很可能是潜在的抗结直肠癌药物。该文旨在综述丁酸钠在结直肠癌细胞凋亡中的作用及机制新进展,并简述丁酸钠在维护肠道微环境、增强肠黏膜的免疫屏障功能和抑制肠道炎症的作用,以期为丁酸钠开发为一线治疗结直肠癌的药物提供参考。

Sodium butyrate is a sodium salt of four-carbon short chain fatty acids produced by dietary fiber under the action of intestinal microorganisms,it can provide energy for intestinal epithelial cells,and plays an important role in maintaining the integrity of intestinal epithelial cells,inhibiting intestinal inflammation and tumor.In recent years,many studies have indicated that sodium butyrate can mediate apoptosis of colorectal cancer cells by inhibiting histone deacetylase activity,cysteine protease mediation and endoplastic reticulum(ER)stress,suggesting that sodium butyrate may be a potential anti-colorectal cancer drug.This article aims to review the advance progress in the role and mechanism of sodium butyrate in colorectal cancer cell apoptosis,and briefly describe the relationship between sodium butyrate in maintaining intestinal microenvironment and enhancing the immune barrier function of intestinal mucosa with inhibiting intestinal inflammation in order to provide reference for the development of sodium butyrate as first-line anti-colorectal cancer drugs.