复方丹参滴丸对慢性心衰患者血管活性物质及炎性因子水平的影响

Effects of Compound Danshen Dripping Pills on Levels of Vasoactive Substances and Inflammatory Factors in Patients with Chronic Heart Failure

目的:探讨慢性心力衰竭(Chronic heart failure,CHF)患者采用复方丹参滴丸治疗的效果。方法:将医院2020年1月~2022年6月收治的CHF患者80例按照随机数表法分为2组,各40例。对照组采用常规治疗,观察组加用复方丹参滴丸治疗,均治疗8周,比较两组治疗效果、血管活性物质及炎症因子水平。结果:观察组治疗总有效率95.00%(38/40),比对照组77.50%(31/40)高(P<0.05);治疗后,两组血管紧张素Ⅱ(Angiotensin II,AngⅡ)、内皮素1(Endothelin 1,ET-1)及脑利钠肽(Brain natriuretic peptide,BNP)水平均比治疗前低,且观察组比对照组低(P<0.05);治疗后,两组超敏C反应蛋白(Hypersensitivity C reactive protein,hs CRP)水平、白细胞介素(Interleukin 6,IL-6)水平均比治疗前低,且观察组比对照组低(P<0.05)。结论:CHF患者采用复方丹参滴丸治疗效果满意,可抑制血管活性物质生存,调节炎性因子水平。

Objective:To investigate the effect of compound Danshen dropping pills on patients with Chronic heart failure(CHF).Methods:A total of 80 CHF patients admitted to our hospital from January 2020 to June 2022 were divided into 2 groups according to random number table method,with 40 cases in each group.The control group was treated with conventional treatment,and the observation group was treated with compound Danshen dripping pills for 8 weeks.The therapeutic effect,vasoactive substances and inflammatory factors were compared between the two groups.Results:The total effective rate of the observation group was 95.00%(38/40)higher than that of the control group 77.50%(31/40)(P<0.05).After treatment,the levels of angiotensin II(AngⅡ),endothelin 1(ET-1),and brain natriuretic peptide(BNP)were lower than before treatment.The observation group was lower than the control group(P<0.05).After treatment,the levels of Hypersensitivity C reactive protein(hs CRP)and Interleukin 6(IL-6)in both groups were lower than before treatment,and the observation group was lower than the control group(P<0.05).Conclusion:The treatment effect of compound Danshen dripping pills in CHF patients is satisfactory,which can inhibit the survival of vasoactive substances and regulate the level of inflammatory factors.