锰纳米佐剂的制备及生物学效应

Preparation of Nano-manganese and Its Biological Effects

锰作为生命活动中重要微量元素参与了多种生理过程。对于能量代谢、神经系统发育和免疫系统正常运行至关重要。与可溶性锰离子相比,纳米锰可维持锰离子在注射部位持续释放,以诱导局部的免疫应答,并增强树突状细胞(dendritic cells,DCs)对抗原的摄取,促进DCs在体内活化与成熟。本文从纳米锰作用机制、制备方法、功能表征、纳米佐剂存在的问题和解决策略等方面进行综述,重点介绍了纳米锰作为疫苗佐剂的应用,并提出存在问题及解决策略。

Manganese is an important trace element that participates in various physiological processes,including skeletal,reproductive,energy metabolism,and normal functioning of the nervous and immune systems.Compared with soluble manganese ions,nano-manganese can maintain the continuous release of manganese ions at the injection site,induce local immune responses,and enhance the cellular uptake of antigens by dendritic cells(DCs),promoting the activation and maturation of DCs in the body.This article reviews the relevant issues of nano-manganese from the perspectives of their mechanism of action,preparation methods,functional characterization,problems with nano adjuvants,and solutions.The application of nano-manganese as vaccine adjuvants was emphasized and the problems and solutions of nano-manganese were proposed.