辐照技术在疫苗研发中的应用

Application of Irradiation Technology in Vaccine Development

病原体灭活是生产灭活疫苗最关键和最基本的技术。理想的灭活方式是彻底灭活病原体并保持抗原的免疫原性,且无化学残留。与传统灭活方式相比,辐照技术在疫苗研发中的主要优势是它能够穿透病原体,但对病原体表面抗原蛋白造成的损伤较小,且灭活后不需要去除任何化学残留物,因此更适合用于研发安全有效的灭活疫苗。本文简要回顾和总结了辐照技术应用于疫苗研发的历史和进展,讨论了辐照技术在疫苗研发中的应用的潜在策略。

Pathogen inactivation is the most critical and basic technology for producing inactivated vaccines.The ideal inactivation method is to completely inactivate the pathogen and maintain the immunogenicity of the antigen without chemical residues.Compared with traditional inactivation methods,the main advantages of irradiation technology in vaccine development are that it can penetrate the pathogen but causes less damage to the pathogen surface antigens,and does not require the removal of any chemical residues after inactivation.Therefore,irradiation technology is more suitable for developing safe and effective vaccines.This article briefly reviews and summarizes the history and progress of using irradiation technology in vaccine development,and discusses potential strategies for developing vaccines using radiation technology.